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Guide to Percocet: Addiction, Effects, & Treatment

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Medically Reviewed By: Diana Vo, LMFT

January 31, 2024

Table of Contents

Percocet addiction can develop rapidly, even when the medication is being used as prescribed.

While the global pandemic may have displaced the opioid epidemic from the media spotlight, we are now witnessing the aftershocks of the stressors caused by coronavirus. SAMHSA recently published data from its annual National Survey on Drug Use and Health (NDSUH 2020). This data shows that of the 9.5 million people who misused opioids in the previous year, 9.3 million misused prescription painkillers like Percocet.

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What is this powerful prescription medication, then?

What is Percocet?

What is a perc, then?

Percocet is a branded opioid pharmaceutical drug typically prescribed for the relief of moderate to severe pain, per the US National Library of Medicine.

Tablets of Percocet contain a combination of oxycodone (otherwise known as hillbilly heroin) and acetaminophen (an OTC analgesic). Acetaminophen is the active ingredient in Tylenol.

Other street names for Percocet include:

  • Perc
  • Blueberries
  • Blue
  • Ercs
  • Bananas
  • 512s
  • Rims
  • Tires

Oxycodone affects how your brain perceives pain, while acetaminophen inhibits the production of pain-related chemicals in the brain.

Under the DEA-regulated Controlled Substances Act, oxycodone is classified as a Schedule II drug. This means it has a legitimate medical use but a strong potential for abuse. Drugs classified under this schedule are the most tightly controlled substances in the United States with accepted medical use.

As with other opioids, Percocet has also been widely prescribed for the treatment of chronic pain, and this is one of the main reasons for the widespread problem in the US with addiction to Percocet and other opioids.

Is Percocet an Opioid?

Percocet is a combination opioid containing oxycodone and acetaminophen.

Percocet Side Effects

Percocet will stay in your system for some time and Percocet abuse can trigger some immediate issues, as well as a battery of adverse long-term consequences.


The most common short-term effects of Percocet include:

  • Vomiting
  • Nausea
  • Dizziness
  • Drowsiness
  • Constipation
  • Difficulty urinating
  • Slowed or irregular breathing

Even in the short-term, abusing this opioid can lead to a heightened tolerance for the substance, initiating a vicious cycle that often ends in addiction.


Long term side effects of Percocet addiction include:

  • Liver damage
  • Constipation
  • Lowered levels of testosterone
  • Impaired sexual function
  • Tolerance
  • Addiction
  • Opioid use disorder

Some typical behavioral symptoms associated with long-term Percocet abuse include:

  • Borrowing or stealing money for this drug
  • Social withdrawal
  • Trying to obtain fraudulent prescriptions
  • Abusing the drug when it is dangerous to do so – while driving or when using other drugs, for instance
  • Stealing the drug
  • Obtaining illicit Percocet
  • Taking more of the drug than intended
  • Using the drug for longer than intended
  • Continuing to abuse the drug despite negative effects

Long-term abuse of Percocet also leads to these physical symptoms:

  • Insomnia
  • Disrupted sleep patterns
  • Shallow breathing
  • Weight loss
  • Slurred speech
  • Withdrawal symptoms when not taking the drug
  • Fatigue
  • Constipation
  • Slowed heart rate
  • Issues with balance and coordination
  • Impaired motor skills

You can also expect the follow cognitive symptoms if you abuse Percocet long-term:

  • Problems with judgment and memory
  • Reduced ability to focus or concentrate
  • Agitation
  • Mood swings
  • Anger
  • Aggression
An image of a person in therapy for Percocet addiction

What Does Percocet Do?

Opioids like oxycodone block pain by disrupting the brain’s chemical pathways associated with pain sensations. Beyond this, opioids slow down certain (central nervous system) CNS functions like heart rate, breathing rate, and blood pressure. Percocet abuse also interferes with your brain’s chemical messengers – neurotransmitters – like dopamine. When opioids cause a spike in dopamine levels, you feel the rewarding, euphoric rush associated with this class of drugs.

Percocet Withdrawal

Percocet is among the most widely misused and abused prescription medications. Like all opioids, abuse of this medication can induce serious side effects, including Percocet drug addiction.

Opioid painkillers like Percocet are highly effective when prescribed short-term, but tolerance swiftly builds, and dependence can soon follow.

Research indicates that opioid abuse can affect areas of the brain like the positive reinforcement structure. This can trigger physical, emotional, and behavioral changes, according to the American Physiological Society. When this occurs, recreational drug abuse becomes compulsive drug use, liable to develop into opioid use disorder.


Mild flu-like symptoms characterize early opioid withdrawal. These include:

  • Chills
  • Hot flashes
  • Sweating
  • Goosebumps
  • Aches and pains
  • Watery eyes and nose

The most intense withdrawal symptoms are as follows:

  • Diarrhea
  • Nausea
  • Vomiting
  • Severe aches and pains
  • Tremors
  • Abdominal cramping
  • Anxiety
  • Insomnia
  • Irritability
  • Fatigue

How Long Does Percocet Withdrawal Last?

While everyone will experience this o pioid addiction in different ways, there is an approximate timeline when it comes to Percocet detox and withdrawal.

Just like every addiction is different, though, so your experience of Percocet withdrawal may differ from the below Percocet addiction timeline.

Here is what you can expect when detoxing and withdrawing from opioid abuse:

Day 1

The short half-life of the drug – just 3.5 hours – means withdrawal symptoms typically manifest from 5 to 8 hours after the last dose.

Days 2 and 3

The most intense symptoms of Percocet withdrawal will peak 2 or 3 days after the last dose, mirroring flu-like symptoms.

Days 4 through 7

The most intense physical symptoms of Percocet withdrawal should start to decline.

Anyone addicted to this drug will experience powerful cravings. These psychological cravings will persist without a psychosocial intervention like counseling or cognitive behavioral therapy.

As you enter the second week opioid-free, you’ll need to address the psychological component of this opioid addiction with the physical symptoms of withdrawal dissipated.

Percocet Addiction Treatment

Treating a Perc addiction can be challenging, but most people respond favorably to personalized treatment.

Rehab for Percocet addiction is similar to that for addiction to other prescription opioids – OxyContin or morphine, for instance.

The most effective treatment for Percocet addiction involves:

  • Medical detox
  • Intensive and integrated treatment – medication assisted treatment, psychotherapy, counseling
  • Aftercare and ongoing support

Percocet detox is usually the most demanding step in this ongoing process, with withdrawal symptoms frequently intense and cravings often powerful. A medical detox can improve your chances of weaning yourself off the drug as comfortably as possible.

Renaissance Recovery logo | Percocet

Percocet Rehab at Renaissance Recovery

Here at Renaissance Recovery Center, our Percocet addiction treatment center in California provides you with the support and structure you need to build a firm foundation for an opioid-free life.

If you have resisted seeking help for Perc addiction because you can’t take a month or more off to attend residential rehab, this need not be a barrier to treatment. Choose one of our outpatient treatment programs for opioid use disorder and access the same services you would find in inpatient rehab more affordably and less restrictively.

For anyone requiring more structure and support in their recovery from Percocet addiction, we offer both IOPs (intensive outpatient programs) and PHPs (partial hospitalization programs) for a more immersive recovery experience.

The Renaissance treatment team at our Florida rehab will use a personalized array of evidence-based treatments to help you combat addiction to opioids. FDA-approved medications can streamline the detox and withdrawal process, and also help you remain abstinent from opioids with less chance of relapsing. Alongside MAT, you’ll have access to counseling and psychotherapy to help you tackle the psychological aspect of addiction to Percocet.

If the pain of Percocet addiction is even greater than the underlying pain it is being used to treat, don’t continue suffering in silence. Reach out to the friendly Renaissance team instead at 866.330.9449.



At Renaissance Recovery our goal is to provide evidence-based treatment to as many individuals as possible. Give us a call today to verify your insurance coverage or to learn more about paying for addiction treatment.

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Joseph Gilmore has been in the addiction industry for three years with experience working for facilities all across the country. Connect with Joe on LinkedIn.

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