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Zoloft Addiction: Signs, Symptoms, & Treatment

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Medically Reviewed By: Diana Vo, LMFT

November 7, 2023 (Originally Published)

January 31, 2024 (Last Updated)

Table of Contents

Zoloft, an SSRI (selective-serotonin reuptake inhibitor), is typically prescribed to alleviate symptoms of depression. That said, some people may misuse this medication as a means of seeking relief from mental health concerns or to manage withdrawal symptoms that arise when attempting to discontinue usage. This guide to Zoloft abuse highlights issues that include:

  • Can you get addicted to Zoloft?
  • Is Zoloft addicting when used as prescribed?
  • Can you abuse Zoloft?
  • What is the main Zoloft addiction risk?
  • How to connect with addiction treatment in California.

Zoloft Addiction Signs

Zoloft, also known by its generic name sertraline, is an SSRI antidepressant that is commonly prescribed to adults for various mental health and mood disorders. It has been demonstrated to effectively enhance and stabilize thoughts, mood, appetite, sleep, and energy levels in individuals diagnosed with conditions such as major depressive disorder, panic disorder, OCD (obsessive compulsive disorder), social anxiety disorder, PTSD (post-traumatic stress disorder), and premenstrual dysphoric disorder. Is sertraline addictive, though?

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Although not viewed as addictive in the sense of delivering a euphoric high, long-term use of the medication may trigger withdrawal symptoms upon discontinuation. Someone who is struggling with Zoloft addiction might encounter symptoms such as:

  • Insomnia
  • Paranoia
  • Depression
  • Aggression
  • Anxiety

Additionally, heightened serotonin levels resulting from Zoloft addiction can potentially lead to serotonin syndrome, characterized by changes in mental status, rhythmic muscle spasms, and autonomic dysfunction. The severity of Zoloft’s side effects is often more pronounced than those associated with other SSRIs. Seek immediate medical attention for severe side effects, including seizures, heart arrhythmias, muscle stiffness, extreme disorientation, and potential liver damage associated with long-term Zoloft abuse.

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Zoloft Addiction Symptoms

Recognizing the signs and symptoms of Zoloft addiction can help in identifying and addressing potential issues early on. Those who abuse Zoloft may exhibit the following signs and symptoms:

  • Compulsive use: Engaging in the compulsive use of Zoloft beyond prescribed or recommended doses, often with an inability to cut down or control usage despite adverse outcomes.
  • Seeking euphoria: Using Zoloft to achieve a sense of euphoria, relaxation, or escape from reality, rather than for its intended therapeutic purposes.
  • Tolerance: Developing a tolerance to the effects of Zoloft, leading to the need for increased dosages to achieve the desired effects, which can contribute to an escalation of use.
  • Withdrawal symptoms: Experiencing withdrawal symptoms such as dizziness, fatigue, irritability, and disturbances in sleep patterns when attempting to reduce or discontinue Zoloft use.
  • Neglecting responsibilities: Prioritizing obtaining and using Zoloft over fulfilling personal, professional, or social obligations, leading to a decline in overall functioning and performance.
  • Continued use despite harm: Persisting in the use of Zoloft despite experiencing detrimental effects on physical health, mental well-being, and interpersonal relationships.
  • Cravings: Experiencing intense cravings or a persistent urge to use Zoloft, leading to preoccupation with obtaining and using the medication.
  • Social and behavioral changes: Exhibiting noticeable changes in behavior, mood swings, increased secrecy, or isolation from loved ones, often accompanied by shifts in social interactions and priorities.
  • Health complications: Developing adverse health effects or complications associated with prolonged Zoloft misuse, potentially leading to severe physiological and psychological disturbances.

Recognizing these symptoms can prompt timely intervention and support, facilitating the initiation of appropriate treatment and the promotion of overall well-being and recovery.

Zoloft withdrawal, a form of SSRI discontinuation syndrome, affects roughly one in five people prescribed SSRIs. Due to Zoloft’s short elimination half-life, sudden cessation can provoke a rapid decline in serotonin levels, resulting in various withdrawal symptoms.

Healthcare professionals commonly adopt a tapering strategy to help people wean off the medication safely and gradually. Withdrawal symptoms typically last for one to three weeks and may include:

  • Chills
  • Dizziness
  • Fatigue
  • Headaches
  • Irritability
  • Insomnia
  • Lack of concentration
  • Lightheadedness
  • Nausea
  • Vomiting
  • Recurring nightmares
  • Vivid dreams
  • Suicidal ideation


Do people abuse Zoloft?

While Zoloft is not typically abused for recreational purposes, some people may misuse it by taking higher doses than prescribed or using it without a prescription, leading to potential health risks and dependency issues.

Is Zoloft addictive?

Zoloft is not considered addictive in the traditional sense, as it does not create a euphoric high or a craving for more of the medication. However, sudden discontinuation of Zoloft can lead to withdrawal symptoms, underscoring the importance of gradually tapering off the medication under medical supervision.

How addictive is Zoloft?

Zoloft is generally not as addictive as substances that produce a euphoric high, such as opioids or stimulants. That said, abruptly stopping Zoloft can lead to withdrawal symptoms like dizziness, fatigue, and irritability.

Zoloft Addiction Treatment

Zoloft addiction treatment normally involves a comprehensive approach tailored to individual needs and circumstances. Various treatment modalities and interventions may be employed to address the physical and psychological aspects of addiction. Some of the common approaches to Zoloft addiction treatment include:

Medical detoxification

Safely tapering off Zoloft under the supervision of medical professionals to manage withdrawal symptoms and minimize potential risks.

Behavioral therapies

Engaging in CBT (cognitive behavioral therapy) or other forms of psychotherapy to identify and address the underlying factors contributing to addiction and develop coping strategies to manage triggers and cravings.

Support groups

Participating in support groups or group therapy sessions can provide peer support and a sense of community, facilitating mutual understanding and shared experiences in the recovery process.

Medication management

In some cases, medication may be prescribed to alleviate specific symptoms or co-occurring mental health conditions associated with Zoloft addiction, such as depression or anxiety.

Dual diagnosis treatment

Addressing any co-occurring mental health disorders alongside Zoloft addiction to ensure comprehensive and integrated care.

Aftercare support

Implementing a structured aftercare plan that may include ongoing therapy, support group participation, regular check-ins with a therapist or counselor, and other resources to help maintain long-term recovery and prevent relapse. Individualized treatment plans, guided by experienced professionals, are crucial for successfully managing Zoloft addiction and promoting sustained recovery and well-being.

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Get Treatment for Zoloft Addiction at Renaissance Recovery

If you need help recalibrating your life from abusing prescription medications like Zoloft, we can help you at Renaissance Recovery in Huntington Beach, CA.

Our outpatient treatment programs offer the most flexible and affordable option for those looking to unpack prescription drug addiction. Choose from a traditional outpatient program, an IOP (intensive outpatient program) or a PHP (partial hospitalization program) depending on your preferences and the severity of your addiction.

All treatment programs at our beachside treatment center blend holistic and science-backed interventions, such as:

Take action today by calling 866.330.9449 and begin your recovery from Zoloft addiction tomorrow.



At Renaissance Recovery our goal is to provide evidence-based treatment to as many individuals as possible. Give us a call today to verify your insurance coverage or to learn more about paying for addiction treatment.

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Joseph Gilmore has been in the addiction industry for three years with experience working for facilities all across the country. Connect with Joe on LinkedIn.

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