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Dangers of Mixing Prozac and Alcohol

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Medically Reviewed By: Diana Vo, LMFT

April 1, 2024 (Originally Published)

April 1, 2024 (Last Updated)

Table of Contents

Prozac, an SSRI antidepressant, is prescribed to manage mental health conditions like depression, which is among the most common mental health disorders. Alcohol, while socially accepted, is also the most abused addictive substance in the United States. Research suggests that combining alcohol and Prozac may stunt the effectiveness of depression treatment and inflame adverse side effects. Read on to learn more about the potential dangers of taking Prozac and drinking alcohol.

Is Mixing Alcohol and Prozac Dangerous?

Individuals grappling with alcohol use disorder  – the clinical descriptor for alcoholism – frequently experience co-occurring mental health conditions like depression. Prozac (fluoxetine) is widely prescribed to treat depression. It belongs to the class of drugs known as SSRIs (selective serotonin reuptake inhibitors).

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Treatments for alcohol use disorder may include medications which negatively interact with alcohol, triggering undesirable side effects and hazards. Prozac and alcohol consumption is particularly inadvisable. The side effects of Prozac and alcohol combined can include intensified sedation and extreme drowsiness. This heightened sedation can precipitate dangerous outcomes, such as compromised decision-making abilities, impaired driving capabilities, and an increased likelihood of falls and injuries, presenting serious risks.

Prozac and Alcohol Side Effects

Mixing Prozac with alcohol can lead to negative side effects that dramatically impact both physical and mental health, including:

  • Heightened sedation: Prozac and alcohol individually have a calming effect on the central nervous system. Together, they amplify this sedation, leading to severe drowsiness and a state of lethargy. This increased sedation can disrupt a person’s ability to focus, make decisions, or carry out everyday activities, increasing the likelihood of accidents or other dangerous situations.
  • Exacerbated drowsiness and fatigue: Both substances can cause feelings of tiredness and a lack of energy. When taken together, these effects are magnified, causing pronounced sleepiness, difficulties in remaining awake, and a decreased state of alertness. This heightened level of fatigue can severely affect daily living and is especially dangerous during tasks that demand concentration and vigilance.
  • Reduced medication efficacy: Drinking alcohol can interfere with the effectiveness of Prozac in regulating brain serotonin levels. Consequently, individuals might not fully benefit from the medication, diminishing its ability to treat depression and other mental health issues.
  • Gastrointestinal issues: Prozac and alcohol can both trigger gastrointestinal problems like nausea, vomiting, diarrhea, or stomach discomfort. The combination of these substances can increase both the likelihood and severity of these issues, causing discomfort and potentially leading to dehydration.
  • Mood fluctuations: The interaction between Prozac and alcohol can undermine the stabilizing effects of the medication on mood. Alcohol can influence mood dynamics, often causing emotional volatility, increased irritability, or deepening depressive states. Mixing it with Prozac may intensify these mood disturbances, provoking greater emotional instability.
  • Cognitive impairment: The mix of Prozac and alcohol can cloud judgment and impede clear thinking. The influence of alcohol on brain function can disrupt the therapeutic effects of Prozac in mood and emotional regulation, potentially worsening symptoms of depression and anxiety.
  • Decreased coordination: Alcohol can impair motor skills and coordination, leading to unsteady movements and a heightened risk of falls. When combined with Prozac, which may also affect coordination, this impairment is accentuated, creating significant safety concerns.
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Alcohol and Prozac Interaction

The Prozac and alcohol interaction is less extreme than the chemical interaction which takes place between alcohol and older types of antidepressants like TCAs (tricyclic antidepressants). SSRIs generally cause less sedation than TCAs. 

Prozac aims to alleviate symptoms of depression by acting on the brain, whereas alcohol is a depressant of the CNS (central nervous system), which regulates most functions of the body and mind. Consuming alcohol can decelerate both bodily and cognitive processes, potentially affecting a person’s mood, behavior, and self-control.

One of the side effects associated with Prozac is fatigue. Given that alcohol also depresses brain and bodily functions, the combined effect may result in heightened sedation or profound drowsiness. The way each person’s body processes medications and substances varies, making it unpredictable how many drinks might trigger this sedated state. For some people, a single drink may lead to adverse outcomes.

While Prozac is an effective treatment for depression, like other SSRIs, it is advisable to avoid alcohol consumption during treatment.

What to Do if You Mixed Prozac and Alcohol

If you find yourself in a situation where you’ve mixed Prozac and alcohol, approach the situation here’s what you can do:

  • Assess your condition: Monitor how you’re feeling. If you experience severe dizziness, excessive drowsiness, difficulty breathing, or any other concerning symptoms, seek medical attention immediately. These symptoms could indicate a severe reaction that requires prompt intervention.
  • Stay hydrated: Alcohol can lead to dehydration and staying hydrated can help mitigate some of the negative effects. Drink plenty of water to help flush the alcohol out of your system more quickly and ease symptoms like headache and dizziness.
  • Avoid risky activities: Given the potential for impaired judgment and coordination, avoid activities like driving, operating heavy machinery, or making important decisions until you fully understand how the combination affects you.
  • Reach out for support: If you’re feeling overwhelmed or unsafe, don’t hesitate to reach out to a friend, family member, or healthcare provider. It’s important to make someone aware of your situation so they can help if your condition worsens.
  • Consult your healthcare provider: Even if you don’t experience severe immediate effects, it’s wise to inform your healthcare provider about the incident. They can offer personalized advice, adjust your treatment plan if necessary, and provide guidance on how to avoid similar situations in the future.
  • Use the experience as an opportunity to learn: Take this experience as an opportunity to learn more about the interactions between your medication and alcohol. Understanding the risks and reasons behind the advice to avoid alcohol can help you make more informed decisions about your health moving forward.
  • Plan for the future: Consider strategies to prevent mixing Prozac and alcohol again. This might involve setting reminders to take your medication at times when you’re less likely to drink, finding non-alcoholic alternatives you enjoy, or seeking support for alcohol use if needed.

Taking proactive steps after mixing Prozac and alcohol can help manage any immediate risks and contribute to your ongoing health and safety.


Is mixing alcohol and Prozac dangerous?

Yes, mixing alcohol and Prozac can be dangerous, as alcohol can intensify the side effects of the medication, such as drowsiness, dizziness, and difficulty concentrating. It may impair your thinking and judgment.

Can Prozac and alcohol kill you?

Although it’s rare, combining Prozac and alcohol can lead to severe and potentially life-threatening conditions, especially if consumed in large quantities. This combination can increase the risk of overdose, respiratory distress, and other serious health issues.

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Get Treatment for Prozac and Alcohol Addiction at Renaissance Recovery

Although Prozac is not addictive in the traditional sense, you may want help if depression is co-occurring with alcohol addiction. If so, reach out to Renaissance Recovery for compassionate dual diagnosis treatment.

Coordinated and integrated treatment for co-occurring disorders like depression and alcohol use disorder consistently delivers superior treatment outcomes. Tackle both conditions head-on during outpatient treatment at our rehab facility in Huntington Beach, CA, while meeting your everyday commitments.

All treatment programs offer individualized treatments that may include:

Call Renaissance at 866.330.9449 for help addressing alcohol addiction and depression in Southern California.



At Renaissance Recovery our goal is to provide evidence-based treatment to as many individuals as possible. Give us a call today to verify your insurance coverage or to learn more about paying for addiction treatment.

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Joseph Gilmore has been in the addiction industry for three years with experience working for facilities all across the country. Connect with Joe on LinkedIn.

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