Wellbutrin vs. Lexapro: Similarities & Differences

When it comes to treating depression and anxiety, finding the right medication can make a huge difference. Two common options doctors prescribe are Wellbutrin and Lexapro. Both are antidepressants, but they work in different ways and can have different effects on people. Understanding how these medications compare can help you make the best choice for your mental health journey.

This guide to Wellbutrin vs. Lexapro explores the similarities and differences between the medications, including how they work, their uses, side effects, and complications. It also outlines how to get effective treatment for prescription drug abuse.

What Is Wellbutrin? Is Wellbutrin an SSRI?

Wellbutrin, also known by its generic name bupropion, is a medication used mainly to treat depression and SAD (seasonal affective disorder). [1]

It works by balancing chemicals in the brain that affect mood and energy levels. Wellbutrin belongs to a class of medications called NDRIs (norepinephrine-dopamine reuptake inhibitors). This means it helps increase the amount of norepinephrine and dopamine, chemicals that help control your mood.

Unlike some other common antidepressants, Wellbutrin is not an SSRI. SSRIs, or selective serotonin reuptake inhibitors, increase serotonin levels in the brain. Wellbutrin targets dopamine and norepinephrine rather than serotonin, which is why it works differently from medications like Lexapro or Prozac.

Many people find Wellbutrin helpful because it tends to have fewer sexual side effects than SSRIs. It can also be used for smoking cessation, helping people quit smoking by reducing cravings and withdrawal symptoms. That said, Wellbutrin isn’t for everyone. Talk to your doctor to see if this medication is the right fit.

What Is Lexapro? Is Lexapro an SSRI?

Lexapro, or its generic version escitalopram, is another popular antidepressant. It is often prescribed to treat depression and anxiety disorders like GAD (generalized anxiety disorder). Lexapro works by increasing levels of serotonin in the brain. Serotonin is a chemical that affects mood, sleep, and even appetite. [2]

Lexapro is an SSRI. SSRIs block the reabsorption of serotonin, making more of it available in the brain. This can help improve mood, reduce anxiety, and help manage symptoms of depression over time. 

Lexapro is generally well-tolerated, and many people find it effective in improving their mental health. It’s often chosen for people with anxiety disorders because it has strong anti-anxiety effects. However, like all medications, it can cause side effects, and might not work the same for everyone. Talking to your healthcare provider about your symptoms and medical history can help determine if Lexapro is the right option.

Wellbutrin Versus Lexapro

When it comes to treating mental health conditions, Wellbutrin and Lexapro are both effective options, but they work differently. Wellbutrin is an NDRI, while Lexapro is an SSRI. Each medication affects the brain differently and may be better suited for different people.

Understanding their specific uses, side effects, drug interactions, and costs can help you and your doctor choose the best option for your situation when choosing between the Lexapro and Wellbutrin combo. 

Lexapro vs. Wellbutrin Uses

Wellbutrin uses

Wellbutrin is approved for treating major depressive disorder and seasonal affective disorder. It’s also commonly prescribed to help people quit smoking because it reduces nicotine cravings. Sometimes, doctors prescribe it off-label for other conditions, like ADHD (attention deficit hyperactivity disorder), and to counteract sexual side effects caused by other antidepressants. [3]

Because it doesn’t target serotonin, Wellbutrin may be a good option for people who don’t respond well to SSRIs. It’s often used when people experience too many side effects with medications that increase serotonin levels. Wellbutrin tends to boost energy and improve focus, making it a suitable option for people with depression who struggle with fatigue or concentration issues.

Lexapro uses

Lexapro is primarily prescribed to treat major depressive disorder and generalized anxiety disorder. As an SSRI, it works by increasing serotonin, which helps regulate mood and reduce anxiety. When considering Lexapro vs Wellbutrin for treating anxiety disorders, Lexapro is particularly effective in easing symptoms of chronic worry and stress.

Lexapro vs. Wellbutrin Side Effects

Wellbutrin side effects

Like all medications, Wellbutrin comes with potential side effects. Some of the most common include: 

• Dry mouth
• Nausea
• Insomnia
• Weight loss
• Headaches
• Dizziness 

One of the benefits of Wellbutrin is that it’s less likely to cause sexual side effects like decreased libido or difficulty achieving orgasm, which are common with SSRIs. However, it does have some risks. Wellbutrin can increase the likelihood of seizures, especially in people with a history of seizures or eating disorders. [4] 

Lexapro side effects

Lexapro, like other SSRIs, can also cause side effects, including:

• Nausea
• Drowsiness
• Insomnia
• Dry mouth
• Increased sweating
• Weight gain

One of the most common complaints with Lexapro and other SSRIs is sexual side effects, including reduced sex drive and difficulty with sexual performance. These side effects may cause some people to stop taking the medication. However, you should discuss concerns with a doctor before stopping any prescribed medication. 

Lexapro can also increase the risk of serotonin syndrome, a rare but serious condition caused by too much serotonin in the body. [5]

Lexapro vs. Wellbutrin Interactions

Wellbutrin interactions

Wellbutrin can interact with many other medications and substances. It’s not recommended to use Wellbutrin with other drugs that lower the seizure threshold, like antipsychotics or certain types of antidepressants. Combining Wellbutrin with alcohol can increase the risk of seizures and other side effects like dizziness or confusion.

People taking blood thinners or medications for heart conditions should be cautious, as Wellbutrin can interfere with these drugs. Avoid taking Wellbutrin with MAIOs (monoamine oxidase inhibitors), as this combination can cause dangerous increases in blood pressure.

Lexapro interactions

Lexapro, like other SSRIs, can also interact with a variety of medications. Combining Lexapro with other SSRIs or SNRIs (serotonin-norepinephrine reuptake inhibitors) can increase the risk of serotonin syndrome. This condition can cause symptoms like confusion, fever, and high blood pressure, and requires immediate medical attention.

Lexapro can also interact with blood thinners, which may increase the risk of bleeding. NSAIDs (nonsteroidal anti-inflammatory drugs) like ibuprofen or aspirin may also increase the chance of bleeding when taken with Lexapro.

Lexapro vs. Wellbutrin Cost Effectiveness

Wellbutrin cost-effectiveness

Wellbutrin is available as both a brand-name drug and a generic (bupropion). The generic form is much more affordable, often costing a fraction of the price of the brand-name version. Without insurance, the cost of Wellbutrin can vary depending on the dose and whether it’s the XL (extended-release) or SR (sustained-release) form.

Many people find Wellbutrin a cost-effective option, especially with the availability of generic versions. Insurance typically covers it, although co-pays will depend on the plan. Discount programs and coupons can lower the cost for those without insurance.

Lexapro cost-effectiveness

Lexapro is also available as a generic (escitalopram), which makes it more affordable than the brand-name version. The cost of Lexapro can be higher than Wellbutrin, but with the generic version, it’s more accessible for many people. Costs can vary without insurance, but it’s usually under $100 for a one-month supply in generic form.

Most insurance plans cover Wellbutrin and Lexapro. People without insurance may find generic versions more budget-friendly, and programs like SingleCare or GoodRx offer significant discounts on these medications. Cost should always be considered alongside effectiveness and side effects when choosing a treatment plan and comparing Lexapro vs Wellbutrin.

Which Is More Effective, Wellbutrin or Lexapro?

When comparing bupropion vs Lexapro, remember that effectiveness can vary from person to person. Both medications are designed to treat depression, but they have different mechanisms of action. 

Wellbutrin’s effectiveness

Wellbutrin is known for boosting energy, improving focus, and having fewer sexual side effects than SSRIs like Lexapro. It can be helpful for people whose depression is marked by low energy, trouble concentrating, or those who have had negative experiences with other antidepressants. Wellbutrin is also commonly prescribed to help people quit smoking, making it a unique option for those dealing with both depression and nicotine addiction.

However, Wellbutrin may not be as effective for people who suffer from anxiety. It can sometimes increase anxiety in certain individuals. Additionally, because it doesn’t target serotonin, it may not be as effective for people whose depression stems from serotonin imbalances.

Lexapro’s effectiveness

Lexapro is highly effective for treating both depression and anxiety. It’s often chosen for people who struggle with a combination of the two, as it helps reduce feelings of worry and stress. As an SSRI, Lexapro works by increasing serotonin levels, which is integral to improving mood and managing anxiety. Many people report feeling a reduction in symptoms like sadness, hopelessness, and anxiety within several weeks of starting Lexapro.

That said, Lexapro can come with side effects like weight gain and sexual dysfunction, which may make it less desirable for some. SSRIs like Lexapro may take longer to show noticeable results compared to Wellbutrin. 

Head-to-head comparisons

Wellbutrin vs SSRI studies show both medications are effective at treating depression, but they excel in different areas. [6] For instance, research has indicated that Wellbutrin may cause fewer sexual side effects, making it a better choice for patients who struggle with this issue. Lexapro, on the other hand, may be more effective for those with anxiety or people who need a medication that primarily targets serotonin.

Your doctor will consider your medical history, symptoms, and personal preferences when recommending medications.

When to Avoid Lexapro

Lexapro is a common choice for treating depression and anxiety, but it’s not the right medication for everyone. Lexapro may not be a safe or effective option in all situations.

• Allergic reactions: If you’ve had an allergic reaction to Lexapro or similar medications, like other SSRIs (such as Zoloft or Prozac), you should avoid taking Lexapro. Signs of an allergic reaction can include itching, rash, difficulty breathing, or swelling. If you experience these symptoms, contact your doctor immediately.
• Suicidal thoughts: Like all antidepressants, Lexapro carries a warning about an increased risk of suicidal thoughts and behaviors, especially in young people under the age of 24. This risk is most significant when starting the medication or after changing the dose. If you or a loved one notice worsening depression, agitation, or unusual changes in behavior, seek medical help immediately.
• Serotonin syndrome: Lexapro increases serotonin levels in the brain, which can lead to a serious condition called serotonin syndrome if too much serotonin builds up. This can happen if you are taking other medications that also increase serotonin, such as other SSRIs, certain pain medications, or supplements like St. John’s wort. Symptoms of serotonin syndrome include confusion, high blood pressure, rapid heart rate, and fever. If you experience these symptoms, you need immediate medical attention.
• Pregnancy and breastfeeding: If you are pregnant or breastfeeding, Lexapro may not be the best choice. Some studies suggest that SSRIs like Lexapro can pose risks to a developing baby, including premature birth or withdrawal symptoms in newborns. [7] Always talk to your doctor about the risks and benefits of taking Lexapro during pregnancy or while nursing.
• Liver or kidney problems: People with liver or kidney disease should use Lexapro cautiously. Your liver and kidneys process and eliminate medications from your body, and if they’re not functioning well, the drug could build up to unsafe levels. Your doctor may need to adjust your dosage or recommend a different treatment.
• Heart conditions: While rare, Lexapro can sometimes affect heart rhythm. If you have a history of heart problems, such as an irregular heartbeat or heart disease, your doctor may suggest avoiding Lexapro or closely monitoring your heart function during treatment.

When to Avoid Wellbutrin

Wellbutrin is an effective option for many people dealing with depression, but there are some circumstances where it should be avoided.

• Seizure disorders: One of the biggest risks with Wellbutrin is the increased chance of seizures. If you have a history of seizures or epilepsy, you should avoid taking Wellbutrin. The risk is especially high if you take larger doses than prescribed, so follow your doctor’s instructions carefully. Even if you don’t have a seizure disorder, certain other health conditions, such as brain injuries or eating disorders, can raise your risk of seizures when using Wellbutrin.
• Eating disorders: People with a history of eating disorders, like anorexia or bulimia, should avoid Wellbutrin. These conditions can cause electrolyte imbalances in the body, which may increase the risk of seizures while taking this medication.
• Alcohol or drug use: Drinking alcohol or using drugs that affect your central nervous system can increase the likelihood of having a seizure while on Wellbutrin. If you regularly drink alcohol or use substances, Wellbutrin might not be a safe option. It’s essential to be upfront with your doctor about any alcohol or drug use so they can make the safest decision for you.
• Suicidal thoughts: Like Lexapro, Wellbutrin carries a warning about an increased risk of suicidal thoughts, especially in people under 24. If you have a history of suicidal thoughts or behaviors, you should be closely monitored by a doctor when starting Wellbutrin. Any sudden changes in mood or behavior should be reported to a healthcare provider.
• Severe anxiety or panic disorders: Wellbutrin is not typically recommended for people with severe anxiety or panic disorders. Because it can increase energy levels and stimulate the nervous system, it may make anxiety worse. If you struggle with anxiety in addition to depression, other medications like SSRIs might be a better option.
• High blood pressure: Wellbutrin can raise blood pressure in some people, especially at higher doses. If you have a history of high blood pressure or heart disease, your doctor may recommend against using Wellbutrin or may monitor your blood pressure closely throughout treatment.
• Pregnancy and breastfeeding: There is insufficient research to confirm whether Wellbutrin is completely safe during pregnancy or breastfeeding. If you’re pregnant, planning to become pregnant, or breastfeeding, talk to your doctor about whether Wellbutrin is the best option for you. In some cases, the benefits of treatment may outweigh the potential risks, but this decision should always be made with a healthcare provider. 

By knowing when to avoid these medications, you can work with your doctor to find the safest and most effective treatment plan for your mental health.

Can You Take Wellbutrin and Lexapro Together?

Wellbutrin and Lexapro can be taken together, but only under the close supervision of a doctor. These two medications work in different ways, and combining them can sometimes help treat depression or anxiety more effectively. Wellbutrin affects norepinephrine and dopamine levels in the brain, while Lexapro increases serotonin. By targeting different brain chemicals, the combination may offer more comprehensive relief for people who have not had success with just one medication.

However, taking both medications at the same time comes with risks. Combining antidepressants can increase the chance of side effects, so your doctor will monitor you closely, especially when starting the medications or adjusting the doses. Do not start or stop either drug without consulting a healthcare provider. Always follow your doctor’s guidance and let them know if you experience new or worsening symptoms.

Why Do Doctors Prescribe Lexapro and Wellbutrin Together?

Doctors may prescribe Lexapro and Wellbutrin together for several reasons, especially when a single medication isn’t enough to manage depression or anxiety. Sometimes, one medication may not fully relieve symptoms, or a person may struggle with side effects from just one drug. Here are a few reasons why doctors might combine these medications:

• Better symptom control: For some people, taking Wellbutrin and Lexapro can provide better control over their symptoms. Since the medications affect different brain chemicals, the combination may address a broader range of symptoms. Lexapro helps increase serotonin, which can improve mood and reduce anxiety, while Wellbutrin boosts energy and focus by targeting dopamine and norepinephrine. This can be helpful for people who experience both depression and anxiety or who have not fully responded to one medication alone.
• Reducing side effects: Another reason doctors might prescribe both Wellbutrin and Lexapro is to reduce side effects. For example, many people who take Lexapro or other SSRIs experience sexual side effects, such as a reduced sex drive. Wellbutrin is less likely to cause these problems and may help counteract them when taken together. By balancing the side effects of both medications, doctors aim to create a more manageable treatment plan.
• Improving energy and motivation: Some people with depression struggle with low energy, lack of motivation, or difficulty focusing. While Lexapro is great for improving mood and reducing anxiety, it may not address issues like fatigue. Wellbutrin, on the other hand, can help improve energy levels and focus. By adding Wellbutrin to Lexapro, doctors may be able to help people feel more energized and motivated.
• When one drug isn’t enough: If a person has tried Wellbutrin or Lexapro alone and hasn’t experienced enough improvement, doctors may combine the two to boost effectiveness. Some people don’t respond fully to SSRIs like Lexapro, while others may not get enough relief from Wellbutrin alone. Combining the two medications can offer a better chance of symptom relief for individuals who don’t respond well to a single drug.

Although combining Lexapro and Wellbutrin can be helpful for some people, remember that not everyone will benefit from this approach. Doctors carefully weigh the potential benefits and risks before prescribing both medications together. If you’re considering combining these drugs, talk to your healthcare provider about your symptoms and treatment options to ensure it’s the best choice for you.

What Conditions Is Wellbutrin Approved to Treat?

The FDA has approved Wellbutrin (bupropion) to treat several conditions. This drug is approved to treat the following:

1. Major Depressive Disorder (MDD):
   Wellbutrin is primarily used to treat MDD, helping to alleviate symptoms such as persistent sadness, loss of interest, and fatigue.
2. Seasonal Affective Disorder (SAD):
   It is also approved for the prevention of seasonal affective disorder, a type of depression that occurs at specific times of the year, usually in the fall and winter.
3. To Quit Smoking (as Zyban):
   Bupropion, under the brand name Zyban, is prescribed to help people quit smoking by reducing cravings and withdrawal symptoms.

These are the primary FDA-approved uses of Wellbutrin, though it is sometimes prescribed off-label for other conditions such as anxiety or ADHD. Always consult a healthcare provider for personalized medical advice.

Receive Insurance-Covered Addiction Treatment at Renaissance Recovery

If you have been misusing prescription drugs and need help getting back on track, reach out to Renaissance Recovery.

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For immediate help tackling Wellbutrin or Lexapro addiction, call 866-330-9449.

Sources

[1] https://www.ncbi.nlm.nih.gov/books/NBK470212/

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5864293/

[3] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC314381/

[4] https://dusunenadamdergisi.org/storage/upload/pdfs/1671633863-en.pdf

[5] https://www.poison.org/articles/lexapro-an-ssri-antidepressant

[6] https://pubmed.ncbi.nlm.nih.gov/18605812/

[7] https://www.ncbi.nlm.nih.gov/books/NBK582639/