Concerta vs. Vyvanse: Differences & Similarities

Finding the right treatment for ADHD can feel overwhelming. With so many medication options, it’s hard to know where to start. For many people, Concerta and Vyvanse are among the most popular choices. Both are stimulant medications that help improve focus, organization, and self-control.

This guide to Concerta vs Vyvanse explores the similarities and differences between these medications, including how they work, their benefits, and potential risks. With the right information, you can work with your doctor to make the best decision for your needs. 

What Is Concerta?

Concerta is a prescription drug often used to treat ADHD (attention deficit hyperactivity disorder). Its active ingredient is methylphenidate, a stimulant that helps improve focus, attention, and impulse control [1].

What makes Concerta unique is its long-acting formula. The pill releases the medication steadily throughout the day, providing symptom relief for up to 12 hours. This is especially helpful for children and adults who prefer not to take multiple doses of medication during the day. 

Concerta comes in tablet form and is available in different strengths, including 18mg, 27mg, 36mg, and 54mg. Most doctors start with a low dose and adjust as needed. That said, Concerta isn’t suitable for everyone, especially those with certain heart conditions or a history of tics or glaucoma [2]. 

What Is Vyvanse?

Vyvanse is another medication commonly indicated to manage ADHD. It contains lisdexamfetamine, a stimulant that helps regulate attention and behavior. In addition to treating ADHD, Vyvanse is also approved to treat binge-eating disorder in adults. 

What sets Vyvanse apart is that it’s a prodrug [3]. This means it only becomes active once your body metabolizes it. Because of this, Vyvanse has a lower risk of being abused than some other ADHD medications. 

Vyvanse comes in both capsules and chewable tablets, making it a good option for people who have trouble swallowing pills. It’s available in various doses, ranging from 10mg to 70mg. Like Concerta, Vyvanse provides long-lasting effects, working for 10 to 12 hours.

Is Vyvanse Methylphenidate

Vyvanse is not methylphenidate. While both are stimulants used to treat ADHD, they belong to different drug families. Methylphenidate, the active ingredient in Concerta, increases levels of norepinephrine and dopamine in the brain, helping improve focus and control impulsive behaviors.

Vyvanse, by contrast, contains lisdexamfetamine, which the body converts into dextroamphetamine. This creates a similar effect by increasing brain activity in areas that regulate attention and behavior. 

Both medications work well for ADHD, but their chemical makeup differs. Some people respond better to one medication than the other, depending on how their body processes it.

Alternatives to Vyvanse

Vyvanse isn’t the only option for managing ADHD. There are several alternatives, both stimulant and non-stimulant, that may be a better fit depending on your needs. 

Other stimulants that may act as a Vyvanse alternative include:

• Concerta (methylphenidate): Works similarly to Vyvanse but has a different release system.
• Adderall (amphetamine/dextroamphetamine): Another stimulant that works quickly and is available in both short-acting (Adderall IR) and extended-release (Adderall XR) forms.
• Ritalin (methylphenidate): Similar to Concerta but shorter-acting, requiring multiple doses per day.

 Non-stimulant alternatives to Vyvanse include:

• Strattera (atomoxetine): A non-stimulant that helps improve focus without the risk of abuse.
• Guanfacine (Intuniv): Often used as a secondary treatment to address impulsivity and hyperactivity.
• Clonidine: Sometimes prescribed for ADHD symptoms, especially in younger children.

Each medication works differently, and your doctor can help you decide which one fits your situation best. 

Focalin vs Vyvanse

Focalin and Vyvanse are both stimulants but differ in their composition and how they work. 

• Focalin: Known generically as dexmethylphenidate, this is a refined version of methylphenidate that works more efficiently and may have fewer side effects. It is available in short-acting and extended-release forms.
• Vyvanse: Lisdexamfetamine is a prodrug that’s converted into dextroamphetamine in the body. It lasts longer than Focalin, often making it more convenient for people who need full-day symptom management. 

When comparing the Vyvanse vs Concerta, Vyvanse is often chosen for its smoother release and longer-lasting effects. Focalin’s targeted formula may be better for those who need shorter durations or respond better to methylphenidate-based medications. 

Lisdexamfetamine vs Vyvanse

Lisdexamfetamine is the main active ingredient in Vyvanse, meaning the two are essentially the same medication.

Lisdexamfetamine is a prodrug, so it does not become active until it’s processed by enzymes in the digestive system. Once metabolized, it turns into dextroamphetamine, which helps improve focus, attention, and impulse control. This design reduces the risk of misuse because it can’t be crushed or injected easily. 

Vyvanse is the only brand name for lisdexamfetamine and there are no generic versions currently available. This can make it more expensive than other ADHD medications, but its effectiveness can make it worth the cost. 

Similarities of Vyvanse and Concerta

Vyvanse and Concerta share many similarities as they are stimulant medications commonly used to treat ADHD. While their chemical makeup and release mechanisms differ, their primary effects and uses overlap significantly. 

• Both are stimulants: Both medications increase dopamine and norepinephrine levels in the brain. These neurotransmitters help improve focus, attention, and impulse control.
• Long-lasting effects: Vyvanse and Concerta are extended-release medications, offering symptom relief for 10 to 12 hours. This makes them convenient for people who need full-day coverage without multiple doses.
• Treatment for ADHD: Both are FDA-approved to treat ADHD in children, teens, and adults. They are often first-line treatments due to their proven efficacy in managing symptoms like hyperactivity and impulsivity.
• Once-daily dosing: Both medications are taken once a day, typically in the morning. This simplifies medication schedules and helps ensure consistent symptom control throughout the day.
• Potential side effects: Side effects like appetite suppression, insomnia, and headaches are common with both medications. These effects are mild and may improve as the body adjusts to the medication.
• Controlled substances: Vyvanse and Concerta are both classified as Schedule II controlled substances [4]. This means they have a risk of misuse or dependence and require careful monitoring by healthcare providers.
• Monitoring for effectiveness: Doctors often use rating scales, feedback from teachers or caregivers, and self-reports to assess how well either medication works. Adjustments to the dose or switching medications may be made based on individual responses.

Despite their differences, Vyvanse and Concerta aim to achieve the same goal: helping individuals with ADHD manage their symptoms and improve their quality of life. Working closely with a healthcare provider helps tailor treatment. 

Differences Between Concerta Versus Vyvanse

Concerta and Vyvanse are stimulants used to treat ADHD, but they vary in how they work and their formulations. 

• Chemical composition: There is a difference between Vyvanse and Concerta in chemical composition. Concerta’s active ingredient is methylphenidate, which increases dopamine and norepinephrine in the brain. Vyvanse contains lisdexamfetamine, a prodrug that is inactive until the body metabolizes it into dextroamphetamine.
• Release mechanism: Concerta uses a unique osmotic-controlled release system, which steadily delivers the drug throughout the day. Vyvanse relies on the body’s enzymes to activate it, providing a smooth and extended effect.
• Forms and dosages: Concerta comes as tablets available in doses from 18 to 54mg. Vyvanse is available as capsules and chewable tablets, with doses ranging from 10 to 70mg. 

These differences may help determine which medication is better suited for individual needs and medication response. 

Benefits

Both Concerta and Vyvanse deliver significant benefits for managing ADHD. These include: 

• Improved focus: Both medications enhance concentration, making it easier to complete tasks at home, work, or school.
• Reduced impulsivity: They help control impulsive actions, leading to better decision-making and social interactions.
• Long-lasting effects: Concerta [provides up to 12 hours of symptom relief. Vyvanse offers a similar duration but may feel smoother because of its prodrug design.
• Convenience: With once-a-day dosing, both are ideal for busy schedules or children who might forget multiple doses. 

These benefits often lead to improved self-esteem and better performance in daily life for people living with ADHD. 

Risks

While both medications are effective, they carry risks that need careful consideration, such as:

• Potential for abuse: Both are Schedule II drugs due to their potential for misuse. Vyvanse’s prodrug nature reduces the likelihood of abuse.
• Heart risks: Both medications can increase blood pressure and heart rate. People with heart conditions should consult a doctor before use.
• Mental health concerns: Some individuals may experience irritability, anxiety, or mood swings. Rare but serious risks include worsening depression or suicidal thoughts. Regular monitoring by a healthcare provider helps minimize these risks.
• Efficacy: Both Concerta and Vyvanse are highly effective for treating ADHD, but their efficacy can vary from person to person.
• Onset and duration: Concerta starts working within 30 to 60 minutes, providing consistent symptom relief throughout the day. Vyvanse may take slightly longer to activate, but its effects are often smoother and last just as long.
• Individual response: Some people respond better to methylphenidate-based medications like Concerta. Others may find lisdexamfetamine-based Vyvanse more effective due to differences in metabolism. 

Side Effects

Both medications have common side effects:

• Concerta: headaches, stomach aches, appetite loss, and insomnia.
• Vyvanse: Dry mouth, insomnia, jitteriness, decreased appetite.

Serious side effects include:

• Concerta: May cause persistent erections in rare cases.
• Vyvanse: Could cause tics or worsen existing ones in 2% of those using the drug.

Most side effects lessen over time as the body adjusts. Report severe or bothersome symptoms to a doctor. 

Which One Is Better for ADHD?

Deciding which medication is better depends on individual needs and the following factors:

• Lifestyle fit: Concerta may be a better option for those who prefer a more immediate effect and steady release. Vyvanse’s prodrug design provides smoother symptom control, which some people prefer.
• Formulation needs: Vyvanse offers chewable tablets, making it ideal for children or adults who struggle with swallowing pills. Concerta’s tablet form requires swallowing and cannot be crushed or chewed. 

Both medications are excellent choices for managing ADHD and the better option is the one that works best for the individual.

Is Vyvanse Better Than Concerta?

Vyvanse may be better than Concerta for some people, depending on specific circumstances:

• Prodrug advantage: Vyvanse’s unique design reduces the risk of abuse and provides smoother symptom management.
• Additional uses: Vyvanse is also approved for treating binge eating disorders, making it more versatile.
• Fewer restrictions: Vyvanse can be used by people with certain conditions like glaucoma which restricts Concerta use. 

Comparing Concerta 54mg to Vyvanse

Comparing specific doses like Concerta 54mg and Vyvanse involves looking at their side effects and effectiveness.

Concerta 54mg is the highest available dose and offers full-day coverage. Vyvanse’s doses go up to 70mg, providing slightly more flexibility for those needing higher coverage. 

Both doses offer powerful symptom management for ADHD, but their differences in formulations may impact how each person experiences relief. 

Concerta 54mg may cause more pronounced side effects like headaches or sleep difficulties. Vyvanse’s prodrug design often results in smoother symptom management and fewer abrupt and jarring side effects. 

The choice between these two doses should be based on how each medication aligns with individual needs.

How To Know if Your Concerta or Vyvanse Is Working

The easiest way to tell if your ADHD medication is working is by noticing improvements in your daily life.

• Increased focus: You may find it easier to stay on task, complete assignments, or follow through with responsibilities.
• Improved mood: Many people feel less frustrated or overwhelmed when their medication works effectively.
• Better organization: Tasks that once felt impossible may now seem manageable.
• Feedback from others: Teachers, coworkers, or family members may notice positive changes in your behavior and focus. 

If side effects outweigh the benefits or symptoms don’t improve, talk to your doctor. They may adjust the dose or switch medications. 

Get Treated in a Luxurious, Science-Backed Addiction Treatment Program at Renaissance Recovery

If you have been misusing medications like Vyvanse or Concerta, we can help you get back on track at Renaissance Recovery. 

We treat all addictions and mental health conditions in an outpatient setting at our Florida and California rehabs. This enables you to get structured and supportive treatment while living at home and continuing at school or work.

Due to the unique aspect of all stimulant addictions, all treatment plans at Renaissance are personalized. Therapies may include: 

• Medication management
• Behavioral therapies
• Motivational therapies
• Counseling
• Family therapy
• Group therapy
• Holistic therapies
• Aftercare 

When you’re ready to address stimulant addiction, call 866-330-9449. 

Sources 

[1] https://www.ncbi.nlm.nih.gov/books/NBK482451/ 

[2] https://www.drugs.com/tips/concerta-patient-tips 

[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC2873712

[4] https://www.deadiversion.usdoj.gov/schedules/schedules.html