Ryzolt Withdrawal: Symptoms, Timeline & Treatment

Ryzolt, a long-acting form of tramadol, is prescribed to manage chronic pain. While it can offer relief, it also carries the risk of dependence. Many people who take Ryzolt for extended periods find that their bodies adapt to the drug, making it difficult to stop without experiencing withdrawal. Withdrawal symptoms of Ryzolt can be painful, both physically and emotionally, and may cause a person to continue using the drug just to feel normal.

Breaking free from Ryzolt involves more than willpower. Detox is the first step toward recovery, but stopping Ryzolt suddenly can be dangerous. Knowing what to expect and how to manage symptoms safely can make a big difference. If you or someone you love is struggling with Ryzolt withdrawal, professional help can provide a safer and more comfortable path forward.

What Is Ryzolt?

Ryzolt is an extended-release form of tramadol, a synthetic opioid used to treat moderate to severe pain [1]. Unlike immediate-release pain medications, Ryzolt provides long-lasting relief by slowly releasing tramadol into the body over time. It was designed for individuals who need continuous pain management rather than short-term relief.

Although tramadol is considered less potent than other opioids, it still carries a high risk of dependence and addiction [2]. Over time, the body adjusts to the drug, leading to tolerance. This means a person may need higher doses to achieve the same level of pain relief, increasing the likelihood of addiction. While Ryzolt was discontinued in the U.S. in 2021, people who previously used it or still have access to tramadol may struggle with Ryzolt withdrawal if they try to quit suddenly. 

What Is Ryzolt Withdrawal Like?

When someone stops taking Ryzolt, their body must adjust to functioning without the drug. Since tramadol affects both opioid receptors and serotonin levels, withdrawal symptoms can be both physically and mentally distressing. Ryzolt withdrawal symptoms often feel like a severe flu combined with intense emotional distress.

Withdrawals from Ryzolt may include:

• Nausea and vomiting
• Diarrhea
• Muscle aches and joint pain
• Sweating and chills
• Insomnia and nightmares
• Irritability and mood swings
• Anxiety and panic attacks
• Depression
• Fatigue and weakness
• Rapid heartbeat
• High blood pressure
• Hallucinations (in severe cases)

Withdrawal symptoms from Ryzolt usually begin within 12 to 24 hours after the last dose. The worst symptoms tend to peak within 2 to 4 days and gradually improve over the next week. However, some people experience lingering effects, such as depression and cravings, for weeks or months.

Why Ryzolt Abuse Causes Withdrawal

Ryzolt affects the brain by altering neurotransmitters responsible for pain relief and mood regulation. Long-term use changes the way the brain functions, making it dependent on the drug to maintain balance. When Ryzolt use suddenly stops, the body struggles to regain normal function, leading to withdrawal.

There are several reasons why people develop dependence on Ryzolt, including:

1. Long-term use: Even when taken as prescribed, using Ryzolt for extended periods increases the risk of dependence.
2. High doses: Taking more than the prescribed amount raises the likelihood of addiction and worsens withdrawals from Ryzolt.
3. Recreational use: Some people misuse Ryzolt for its euphoric effects, leading to rapid dependence.
4. Underlying mental health conditions: People with anxiety, depression, or PTSD may rely on Ryzolt for emotional relief, making Ryzolt withdrawal even more difficult.

Because Ryzolt affects serotonin and norepinephrine levels, withdrawal can include severe mood-related symptoms, unlike withdrawal from traditional opioids. This makes quitting without medical support even harder. 

What Is Ryzold Detox Like?

Detox is the process of clearing Ryzolt from the body while managing withdrawal symptoms. Since withdrawal can be painful and unpredictable, medical detox is often recommended.

 There are two main approaches to detoxing from Ryzolt:

1. Tapering: A doctor gradually lowers the dose of Ryzolt over time to reduce the severity of withdrawal. This approach minimizes discomfort and helps the body adjust more smoothly.
2. Medical detox: In a supervised setting, healthcare professionals provide medications and support to ease symptoms. This may include non-opioid pain relievers, sleep aids, and medications that stabilize mood. During medical detox, patients may receive IV fluids to prevent dehydration from vomiting and diarrhea, medications to control nausea and muscle pain, anxiety-reducing treatments to manage panic attacks, and antidepressants or other supportive medications if needed.

Since Ryzolt withdrawal can cause psychological distress, detox centers provide emotional support to help patients cope. Without proper care, withdrawal symptoms can lead to relapse, as individuals may return to the drug just to stop feeling sick. 

What Happens After Ryzolt Detox?

Detox is only the first step in recovery. After the body is free from Ryzolt, the focus shifts to long-term treatment and relapse prevention.

 Post-detox treatment options include:

• Inpatient rehab: A structured environment where individuals receive therapy, medical care, and support to build a drug-free life.
• Outpatient programs: A more flexible option for those who need treatment while maintaining daily responsibilities.
• Counseling and therapy: Behavioral therapies, such as CBT (cognitive behavioral therapy), help address the root causes of addiction [3].
• Support groups: Groups like NA (Narcotics Anonymous) provide community support and accountability.
• MAT (medication-assisted treatment): In some cases, doctors may prescribe medications to help with cravings and prevent relapse [4].

Long-term recovery from Ryzolt addiction requires more than just detox. Therapy, lifestyle changes, and a strong support system all play a role in maintaining sobriety. With the right help, it is possible to regain control and live a healthier, drug-free life. 

FAQs

How long does it take for a withdrawal?

Ryzolt withdrawal timelines vary depending on the drug, dosage, and length of use. For Ryzolt (tramadol extended-release), withdrawal symptoms typically begin within 12 to 24 hours after the last dose and can last up to 10 days. Some psychological symptoms, like anxiety and cravings, may persist for weeks.

What are the side effects of loxapine withdrawal?

Loxapine withdrawal can cause symptoms like nausea, headaches, insomnia, anxiety, and mood swings. In severe cases, individuals may experience hallucinations or a return of psychotic symptoms. Gradual tapering under medical supervision can help reduce withdrawal effects.

How long does it take for tramadol to get out of your system?

Tramadol has a half-life of about six hours, meaning it takes a day or two for most of the drug to leave the body. However, extended-release versions like Ryzolt may take longer. In general, tramadol can be detected in urine for up to four days and in hair for several months.

What are the worst side effects of tramadol?

Severe tramadol side effects include seizures, respiratory depression, serotonin syndrome, and life-threatening allergic reactions. Long-term use or high doses can increase the risk of addiction and overdose, especially when combined with other substances like alcohol or benzodiazepines.

Get Treatment for Ryzolt (Tramadol) Withdrawal at Renaissance Recovery

If you or someone you care about needs help getting off Ryzolt, reach out to Renaissance Recovery. We can help you find medical detox centers near you to streamline the Ryzolt detox process and prepare you for ongoing treatment at one of our California or Florida rehab centers.

Once you have detoxed, you can move into an outpatient treatment program at one of our beachside facilities. We offer programs at varying intensity levels to suit the severity of your opioid addiction and your personal needs. You can continue living at home while attending therapy sessions at Renaissance around your everyday obligations.

All opioid addictions are different, so all our treatment programs are personalized to reflect this. Therapies include:

• MAT (medication-assisted treatment)
• Talk therapies
• Motivational therapies
• Counseling
• Group therapy
• Family therapy
• Holistic treatments
• Aftercare planning

When you’re ready to kickstart your recovery from Ryzolt addiction, call 866-330-9449.

Sources

[1] https://www.ncbi.nlm.nih.gov/books/NBK537060/

[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC8583742/

[3] https://www.apa.org/ptsd-guideline/patients-and-families/cognitive-behavioral

[4] https://www.fda.gov/drugs/information-drug-class/information-about-medications-opioid-use-disorder-moud