Rohypnol Withdrawal Symptoms, Timeline, & Treatment

Rohypnol, also known as flunitrazepam, is a powerful benzodiazepine that can cause deep sedation, memory loss, and physical dependence. Although illegal in the United States, it is still misused worldwide for its calming and euphoric effects. With long-term use, the body adapts to the drug, making it harder to stop without experiencing withdrawal. People who try to quit suddenly may face severe Rohypnol withdrawal symptoms, including anxiety, muscle pain, and even life-threatening seizures.

Withdrawal symptoms of Rohypnol can be dangerous without medical supervision. Symptoms often appear within a day of the last dose and can last for weeks. Some people experience lingering anxiety and insomnia long after the drug has left their system. Understanding the Rohypnol withdrawal process and seeking proper detox care can help make recovery safer and more manageable.

Why Does Rohypnol (Flunitrazepam) Cause Withdrawal And Detox Symptoms?

Rohypnol belongs to the benzodiazepine class of drugs, which work by slowing down brain activity and producing a calming effect [1]. It enhances the effects of GABA (gamma-aminobutyric acid), a neurotransmitter that reduces nervous system activity. This is what makes the drug so effective at inducing sedation, relaxation, and even amnesia. That said, long-term use causes the brain to rely on Rohypnol to maintain chemical balance.

When someone takes Rohypnol regularly, their brain becomes dependent on the drug to function normally. If they suddenly stop using it, the central nervous system becomes overstimulated, leading to withdrawal symptoms upon discontinuation. Since Rohypnol is a potent benzodiazepine—about 10 times stronger than Valium—withdrawal can be more severe than with other drugs in this class. The brain struggles to adjust, causing physical and psychological symptoms that range from mild discomfort to life-threatening seizures.

 Several factors influence the intensity of Rohypnol withdrawal symptoms, including:

• Length of use: The longer someone takes the medication, the harder Rohypnol withdrawal can be.
• Dosage: Higher doses cause stronger dependence, making flunitrazepam symptoms worse during withdrawal.
• Method of use: Swallowing pills has a slower effect than crushing and snorting them, but both lead to dependence.
• Polydrug use: Combining Rohypnol with alcohol, opioids, or other benzodiazepines can complicate withdrawal.
• Underlying health conditions: Anxiety disorders, depression, and other mental health conditions can make withdrawal symptoms more intense.

Benzodiazepine withdrawal is one of the most dangerous types of drug withdrawal [2]. Symptoms can escalate quickly, and quitting suddenly without medical supervision can lead to life-threatening complications. Tapering the dose under a doctor’s guidance helps reduce risks and makes withdrawal more manageable.

Rohypnol Withdrawal and Detox Symptoms

The after-effects of Rohypnol affect both the body and mind, often causing extreme discomfort. Symptoms typically begin within 24 hours after the last dose and can last several weeks. For those wondering, “How long does Rohypnol stay in your system,” it’s  a long-acting benzodiazepine, so it remains in the body longer than short-acting benzos like Xanax, prolonging Rohypnol withdrawal [3].

 Common symptoms of Rohypnol withdrawal include:

• Anxiety and panic attacks
• Restlessness and agitation
• Nausea and vomiting
• Insomnia and frequent waking
• Sweating and chills
• Headaches and dizziness
• Muscle cramps and stiffness
• Increased heart rate and high blood pressure
• Irritability and mood swings

These symptoms can feel overwhelming, but they are typically not life-threatening. That said, some people experience more severe symptoms that require emergency medical care.

 Severe symptoms associated with Rohypnol withdrawal may include:

• Hallucinations (seeing or hearing things that aren’t there)
• Seizures, which can cause permanent brain damage or death
• Delirium, confusion, and memory loss
• Extreme dehydration from vomiting and excessive sweating
• Depression and suicidal thoughts

The most dangerous withdrawal symptom is seizures. People who have used Rohypnol for long periods are at higher risk, especially if they quit suddenly. Seizures can happen days after stopping the drug and may be fatal without medical treatment.

Because withdrawal symptoms can be unpredictable, medical detox is the safest way to stop using Rohypnol. A supervised detox program can help manage symptoms, prevent complications, and provide emotional support throughout the process.

Rohypnol (Flunitrazepam) Withdrawal Timeline

The withdrawal timeline for Rohypnol varies from person to person, depending on factors like dosage, duration of use, and overall health. However, most people experience withdrawal symptoms in two main phases: the acute phase, where symptoms peak and are most intense, and the protracted withdrawal phase, where lingering effects can last for weeks or months.

 Since Rohypnol is a long-acting benzodiazepine, symptoms may not appear immediately after the last dose. Many people start experiencing withdrawal within 24 to 48 hours, with symptoms worsening over the next few days. The most severe phase usually lasts one to two weeks, but some psychological symptoms—such as anxiety, depression, and cravings—can persist much longer.

The following timeline provides a general idea of what to expect during withdrawal. However, the process can vary, and medical supervision is strongly recommended to prevent complications like seizures or severe dehydration.

 Day 1 of Rohypnol Withdrawal

The first signs of withdrawal typically begin 24 to 48 hours after the last dose. At this stage, symptoms may be mild but can quickly escalate. Many people feel restless, anxious, or irritable as their brain begins adjusting to the absence of the drug.

 Common symptoms during day 1 include: 

• Mild anxiety and nervousness
• Headaches
• Irritability and mood swings
• Nausea and stomach discomfort
• Insomnia or difficulty staying asleep
• Increased heart rate

Some people may not experience severe symptoms on the first day, but they often notice an uneasy feeling, similar to caffeine withdrawal or the start of the flu. Those who have used Rohypnol heavily or for an extended period may feel symptoms more intensely right away.

Days 2 and 3 of Rohypnol Withdrawal

By the second or third day, symptoms usually become much more intense. This is when most people feel the worst effects of Rohypnol withdrawal, especially if they have stopped using the drug suddenly. The brain and body are in a state of hyperactivity, leading to severe anxiety, agitation, and physical discomfort.

 Common symptoms during days 2 and 3 include: 

• Extreme restlessness and panic attacks
• Tremors and muscle stiffness
• Nausea, vomiting, and diarrhea
• Sweating and chills
• Increased blood pressure and heart rate
• Difficulty concentrating or mental fog
• Heightened sensitivity to light and sound

 For some, severe withdrawal symptoms may begin during this period. These can include hallucinations, paranoia, and confusion. People with long-term dependence are at high risk for seizures, which can be life-threatening. This is why medical detox is strongly recommended—doctors can provide medications to reduce seizure risk and keep patients stable.

 Days 4-6 of Rohypnol Withdrawal

By days four through six, symptoms typically peak and then begin to ease. However, this phase can still be extremely uncomfortable, and some symptoms may persist for longer.

 Common symptoms during this phase of Rohypnol withdrawal include:

• Severe insomnia and frequent waking
• Continued anxiety and irritability
• Muscle aches and weakness
• Depression and mood swings
• Cravings for Rohypnol
• Fatigue and lack of energy

 For most people, physical symptoms improve by the end of the first week. However, psychological symptoms—such as depression, anxiety, and cravings—can persist for weeks or even months. This is why continued treatment, such as therapy and support groups, is often necessary to prevent relapse.

 While withdrawal can be overwhelming, it is temporary. With proper medical care, hydration, and support, recovery is possible. The next step after detox is finding long-term treatment to address the emotional and mental effects of addiction.

Potential Risks Of Rohypnol (Flunitrazepam) Withdrawal And Detox

Withdrawing from Rohypnol can be dangerous, especially without medical supervision. Since this drug is a potent benzodiazepine, quitting suddenly can cause severe and even life-threatening symptoms. The most serious risks include seizures, hallucinations, extreme dehydration, and suicidal thoughts.

One of the biggest dangers of Rohypnol withdrawal is seizures, which can occur several days after stopping the drug. Seizures caused by benzodiazepine withdrawal can be severe, leading to permanent brain damage or even death in some cases. This is why a medical detox program is strongly recommended—doctors can provide medications to prevent seizures and keep symptoms under control.

Another risk is delirium and hallucinations, which can cause confusion, paranoia, and dangerous behavior. Some people may see or hear things that aren’t there, making them more likely to harm themselves or others. Severe dehydration is another concern, as withdrawal can cause excessive sweating, vomiting, and diarrhea, leading to dangerously low fluid levels.

Psychological effects can also be severe and long-lasting. Many people experience intense anxiety, panic attacks, and depression, which may increase the risk of self-harm or suicide. In some cases, PAWS (post-acute withdrawal syndrome) can cause lingering symptoms for months, making relapse more likely [4].

Because of these risks, stopping Rohypnol should never be attempted alone. A medically supervised detox provides around-the-clock monitoring, medications to ease symptoms, and emotional support to make withdrawal as safe as possible. Seeking professional help can mean the difference between a dangerous withdrawal and a successful recovery.

Get Help with Rohypnol Addiction Treatment at Renaissance Recovery

If you need help for yourself or a loved one battling Benzo addiction, contact Renaissance Recovery today. We can help you find detox centers near you to help streamline the withdrawal process and stabilize you for ongoing treatment.

 When transitioning to outpatient treatment at Renaissance, you can live at home and attend therapy sessions at one of our California or Florida rehab centers while meeting your daily commitments.

 All benzo addictions are different, so all Renaissance treatment plans are customized. Treatments include:

• Medication management
• Motivational therapy
• Counseling
• Talk therapy
• Group therapy
• Family therapy
• Holistic treatments
• Aftercare planning

 Begin your recovery today by calling 866-330-9449.

Sources

[1] https://www.dea.gov/factsheets/rohypnol

[2] https://pubmed.ncbi.nlm.nih.gov/7841856/

[3] https://www.drugs.com/illicit/rohypnol.html

[4] https://sbmi.uth.edu/heroes/documents/Post-Acute-Withdrawal.pdf