Kratom Side Effects and Risks

kratom side effects

Updated January 18, 2026

Written By:

Dr. Matt A. D’Urso
LMHC, LPCC

Content Manager:

Amy Leifeste

Editor:

Karena Mathis

Written By:

Dr. Matthew A. D’Urso LMHC, LPCC

Content Manager:

Amy Leifeste

Editor:

Karena Mathis

kratom side effects

Table of Contents

Treatment for Kratom Addiction

Kratom is a plant-based drug that some people use for energy, pain relief, or to help with withdrawal from other drugs. However, kratom also comes with serious dangers, including dependence, harmful side effects, and even the risk of overdose.

While it may seem natural because it comes from a plant, that doesn’t mean it’s safe. This guide explores what kratom is, how it works, and the risks involved. You will also discover how to get compassionate and effective treatment for substance abuse.

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What Is Kratom?

Kratom is a plant that comes from Southeast Asia, where it has been used for centuries. The plant’s leaves have natural chemicals that can affect the brain. People take kratom for many reasons, such as increasing energy or easing pain. Low doses of kratom act like a stimulant, making people feel more alert and awake. Higher doses work more as a sedative, calming the body and relieving discomfort. In recent years, kratom has become popular in the U.S., but it is still not well understood and can have dangerous side effects.

Even though some people think it’s a natural alternative to medicine, kratom isn’t regulated, and there are concerns about its safety – just because something is plant-based doesn’t mean it’s safe to use.

Mitragyna Speciosa Leaf

Kratom comes from the leaves of a tropical tree called Mitragyna Speciosa, which grows in Thailand, Indonesia, and Malaysia. The leaves contain two key substances – mitragynine and 7-hydroxy mitragynine. These substances interact with receptors in the brain, much like opioids, which is why kratom can have powerful effects.

Traditionally, people in Southeast Asia would chew the fresh leaves or brew them into a tea to relieve pain or boost energy for working long hours. Today, kratom is often sold in powders, capsules, or extracts. However, the strength of kratom can vary, making it hard to predict its effects. People who use kratom may face unexpected side effects like addiction or overdose risks.

Ways to Take Kratom

There are several ways people consume kratom, depending on the form they have. Here are the most common methods:

  • Kratom powder: The leaves can be dried and ground into a fine powder, often mixed into drinks like water, juice, or smoothies, or stirred into tea or yogurt.
  • Kratom capsules or pills: Convenient capsule or tablet form allows measured dosing and avoids the bitter taste of kratom.
  • Kratom drink: Brewing kratom leaves or powder into tea is a traditional and natural consumption method.
  • Kratom gummies: Sweets infused with kratom take 30–60 minutes to kick in, with effects lasting several hours.
  • Kratom extracts: Concentrated forms made by boiling and reducing kratom leaves provide faster, stronger effects but increase risk of side effects and addiction.

Each method has risks, especially since kratom strength varies greatly between products. Without regulation, doses are unpredictable and potentially dangerous.

What Does Kratom Do?

Kratom’s effects depend on the dose. Small amounts act like a stimulant, providing energy and alertness, sometimes enhancing mood and sociability. Larger doses act as a sedative, promoting relaxation, pain relief, and sleepiness. Effects vary by person, type, and amount consumed.

Some people use kratom as an alternative to prescription medications for pain relief or opioid withdrawal. However, using kratom is not without risk.

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Kratom Side Effects

Kratom may seem natural, but it can have serious physical and mental side effects even at low doses, worsening with long-term use.

Short-Term Effects

  • Nausea and vomiting: Can upset the stomach.
  • Dry mouth: Can lead to dehydration if not addressed.
  • Increased urination: Frequent urination may cause fluid loss.
  • Constipation: Slows digestion, causing discomfort.
  • Dizziness and drowsiness: May make driving or operating machinery dangerous.
  • Loss of appetite: Can lead to unhealthy weight loss.

Long-Term Effects

  • Addiction: Kratom can be highly addictive, leading to dependence and withdrawal symptoms.
  • Weight loss and malnutrition: Suppresses appetite, causing significant health issues.
  • Liver damage: Long-term use may cause jaundice or other liver problems [5].
  • Mental health issues: Can cause anxiety, depression, mood swings, hallucinations, or delusions.
  • Insomnia: Regular use can disrupt sleep patterns.
  • Severe constipation: Can lead to digestive complications like hemorrhoids or blockages.

Kratom Warnings & Dangers

Kratom is not regulated. Products vary in strength and may contain harmful substances, making use unpredictable. Regular use can also lead to addiction, as kratom interacts with opioid receptors in the brain. Side effects like nausea, dizziness, liver damage, or hallucinations are possible, and long-term use can exacerbate mental health issues.

Is Kratom Bad for You?

Kratom can be harmful, especially in high or regular doses. Even plant-based substances can affect brain and body function, with risks increasing over time.

Kratom Interactions

Kratom can interact dangerously with other substances:

  • Prescription medications: May reduce effectiveness or increase side effects; combining with opioids or sedatives increases overdose risk.
  • Alcohol: Can intensify drowsiness, dizziness, liver strain, or even cause death.
  • Other drugs: Interactions with illegal drugs or substances like fentanyl or cocaine can lead to heart problems, seizures, or respiratory failure.

Kratom Addiction Risk

Regular use can lead to tolerance, dependence, and withdrawal symptoms similar to opioids. Mental addiction is also possible, affecting daily life and relationships.

Can You Die from Kratom Overdose?

While rare, kratom overdose can be fatal, especially when mixed with other drugs or taken in high doses. Symptoms include slowed breathing, confusion, dizziness, unconsciousness, and seizures.

Lack of Kratom Regulation and Research

Kratom is not FDA-regulated in the U.S., meaning product strength, purity, and safety are untested. Some products may contain harmful substances like heavy metals or bacteria. Research is limited, so using kratom is risky. The safest approach is to avoid kratom or consult a healthcare professional.

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Sources

  1. https://www.sciencedirect.com/topics/medicine-and-dentistry/mitragyna-speciosa
  2. https://onlinelibrary.wiley.com/doi/full/10.1111/add.16366
  3. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670991/
  4. https://nida.nih.gov/research-topics/kratom
  5. https://www.sciencedirect.com/science/article/pii/S0168827823003112
  6. https://www.ncbi.nlm.nih.gov/books/NBK571020/
  7. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8583742/
  8. https://www.fda.gov/news-events/public-health-focus/fda-and-kratom/
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