How Long Does Lexapro Stay in Your System?

Lexapro – escitalopram – is a medication commonly used to treat anxiety and depression. If you’re taking Lexapro or thinking about starting it, you may wonder how long it stays in your body and how your body processes it.

This page explores how Lexapro interacts with your brain and body, how long does Lexapro stay in your system, and what to expect when using or stopping the medication. Whether you’re starting treatment or dealing with side effects, read on to learn more about Lexapro and find out how to get effective treatment for prescription drug abuse.

What Is Lexapro?

Lexapro is a prescription medication often used to treat depression and anxiety. It belongs to a group of drugs called SSRIs (selective serotonin reuptake inhibitors). These medications help improve mood by balancing chemicals in the brain. Lexapro works by increasing serotonin levels. Serotonin is a neurotransmitter responsible for regulating mood, sleep, and emotions. [1]

 This medication is commonly prescribed because it’s known to be effective and is generally well-tolerated by many people. Lexapro comes in tablet form and a liquid solution, making it easier for people to take based on their needs. It’s usually taken once a day, with or without food.

Escitalopram

Escitalopram is the active ingredient in Lexapro. This is the chemical that makes the medication work. Lexapro is the brand name, while escitalopram is the generic form. Both work the same way in the body, but some people prefer the brand version, while others may opt for the generic due to cost or availability.

Escitalopram is designed to treat conditions like depression and GAD (generalized anxiety disorder). It works by increasing the amount of serotonin in the brain. Serotonin plays a major role in how you feel emotionally and mentally. When serotonin levels are too low, it can lead to mood disorders like depression. [2] Escitalopram helps to restore the balance of this important chemical, which can improve mood, reduce anxiety, and increase feelings of well-being.

How Lexapro Interacts with Your Body & Brain

Lexapro interacts with serotonin, one of the brain’s key neurotransmitters. Neurotransmitters are chemicals that send signals between nerve cells in the brain. When you take Lexapro, it blocks the reuptake (or re-absorption) of serotonin, meaning more serotonin stays in the brain for a longer time. This helps stabilize your mood and reduce feelings of depression or anxiety. 

Lexapro doesn’t work instantly. It can take several weeks before you feel the full effects. That’s because your brain needs time to adjust to the increased serotonin levels. You may notice mood, energy levels, and overall mental health gradually improve.

Your body also plays a role in how Lexapro is processed. The liver breaks down the medication into substances later removed from your body, mostly through urine. This process can vary depending on age, liver function, and metabolism.

Common Uses of Lexapro

Lexapro is primarily prescribed for two conditions: 

1. Major depressive disorder: People with depression often feel sad, hopeless, and lose interest in activities they once enjoyed. Lexapro helps by improving mood and energy levels, making it easier to handle daily life.
2. Generalized anxiety disorder: This common anxiety disorder causes excessive, uncontrollable worry about many things, from everyday situations to potential problems that may never happen. Lexapro helps reduce anxiety and its physical symptoms, such as restlessness, tension, and difficulty concentrating.

In addition to these two main uses, Lexapro is sometimes prescribed for other conditions, such as panic disorder, OCD (obsessive-compulsive disorder), and social anxiety disorder. These are called off-label uses, meaning doctors may prescribe it for conditions that aren’t officially approved but where Lexapro may still help. [3]

Lexapro is a powerful tool in managing mental health conditions, helping to create emotional balance and improve quality of life. Take it as prescribed and follow your doctor’s instructions closely.

What Is the Lexapro Half Life & How Long Does Lexapro Last?

The half-life of a drug is the time it takes for half of the medication to leave your body. For Lexapro, the half-life is about 27 to 32 hours. This means it takes just over a day for the amount of Lexapro in your system to decrease by half. However, it usually takes 5 to 6 half-lives for the drug to be almost completely cleared from your body. So, Lexapro may stay in your system for about 6 to 7 days after your last dose.

Even though the medication is processed and leaves your body relatively quickly, the effects of Lexapro can last longer. It often takes a few weeks for your brain to adjust to the changes in serotonin levels. That’s why Lexapro should not be stopped suddenly, as this can cause withdrawal symptoms like dizziness, nausea, or anxiety. Always talk to your doctor before making any changes to your dosage.

Lexapro Dosages

People prescribed Lexapro may have questions like “How long does 5mg of Lexapro stay in your system” or “How long does 10mg of Lexapro stay in your system”. Lexapro comes in different dosages depending on what it is being used to treat and how your body responds to the medication. The typical starting dose for adults is 10mg per day, but some people may be prescribed 5mg if they are sensitive to the medication or are elderly. The maximum dose is usually 20mg per day. 

For treating major depressive disorder and generalized anxiety disorder, the standard dosage is 10mg, but your doctor may increase it to 20mg if necessary. Sometimes, if the lower dose isn’t working well enough, your doctor will increase it after a week or two.

If you’re just starting Lexapro, your doctor will likely start you on a lower dose and gradually increase it to avoid side effects like nausea, fatigue, or dizziness. Always follow your doctor’s instructions, and don’t adjust your dosage. It can take 4 to 6 weeks for the full effects of Lexapro to be felt, so patience is key. 

Controlled Substance Classification

Lexapro is not a controlled substance. This means it is not considered to have a high potential for abuse or addiction, unlike drugs such as opioids or stimulants. However, even though it’s not addictive in the way that some drugs are, you should still take Lexapro only as prescribed.

Some people worry that they might become dependent on Lexapro because they feel better while taking it. While Lexapro can improve your mental health, it doesn’t cause cravings or the kind of physical dependence that comes with controlled substances. If you need to stop taking it, your doctor will help you gradually reduce the dose to avoid any withdrawal symptoms.

How to Store & Dispose of Lexapro

Properly storing and disposing of medications like Lexapro is essential for safety and effectiveness. Here’s how you can manage it: 

• Storage: Keep Lexapro in a cool, dry place, away from direct sunlight and moisture. It’s best to store it at room temperature, ideally between 68°F and 77°F. Keep the medication in its original packaging to protect it from the elements and ensure it doesn’t get mixed up with other medications. Lexapro should also be stored out of reach of kids and pets to prevent accidental ingestion – this can trigger serious side effects or poisoning. A high cabinet or a locked drawer is a good place to keep it.
• Disposal: When Lexapro is no longer needed or has expired, dispose of it properly. Do not flush Lexapro down the toilet or throw it in the trash, as this can contaminate water supplies or pose a risk to others who may come across it. The best way to dispose of unused or expired Lexapro is through a drug take-back program. Many pharmacies, hospitals, or local health departments offer these programs, where you can safely drop off medications. If this option isn’t available, mix the pills with something undesirable, like coffee grounds or cat litter, and place them in a sealed plastic bag before putting them in the trash. This helps ensure that no one else will accidentally or intentionally take the medication.

Risks of Taking Lexapro

Like all medications, Lexapro comes with potential risks. It is generally safe when taken as prescribed, but some people may experience side effects or complications. Understanding the risks can help you make more informed decisions about your treatment. Lexapro may cause both short-term and long-term side effects. Stopping the medication abruptly can lead to withdrawal symptoms. Additionally, mixing Lexapro with other substances like alcohol or certain medications can increase risks. 

Consult your doctor about any concerns or side effects and to follow their guidance on how to take Lexapro safely.

Short-Term Side Effects of Escitalopram

When you first start taking escitalopram, your body may take some time to adjust. This adjustment can lead to short-term side effects that usually go away after a few days or weeks. Common short-term side effects include:

• Nausea: Some people may feel nauseous, especially when they first start the medication. Taking Lexapro with food can help ease this symptom.
• Drowsiness: Feeling more tired than usual is a common side effect. Avoid driving or operating heavy machinery until you know how Lexapro affects you.
• Dizziness: You might feel lightheaded or dizzy, especially when standing up quickly. This usually goes away after your body gets used to the medication.
• Dry mouth: Some people may experience a dry mouth, which can be uncomfortable but is usually manageable by drinking more water.
• Insomnia:  Trouble sleeping or staying asleep is another possible side effect. Try taking Lexapro earlier in the day if it interferes with your sleep.
• Increased sweating: You might notice more sweating than usual, especially at night. This is usually mild and tends to improve over time.

These side effects are usually mild and temporary. If they become too bothersome or don’t go away, talk to your doctor. They may adjust your dosage or suggest ways to manage the symptoms. 

Long-Term Side Effects of Escitalopram

While Lexapro is considered safe for long-term use, there are some side effects that may persist or develop over time. Monitor these with your doctor’s help, especially if you’ve been taking Lexapro for several months or years. Common long-term side effects include: 

• Weight changes: Some people may experience weight gain or weight loss while taking Lexapro. This can happen due to changes in appetite or metabolism. [4]
• Sexual side effects: A common long-term side effect is difficulty with sexual function, including reduced interest in sex, difficulty achieving orgasm, or erectile dysfunction.
• Fatigue: While some people feel more energized after their symptoms improve, others may continue to feel more tired than usual.
• Emotional numbness: Some people may feel emotionally flat or detached after taking this medication. This can happen if it dulls both positive and negative emotions.
• Bleeding risks: SSRIs like Lexapro can slightly increase the risk of bleeding, especially if you are also taking blood thinners or anti-inflammatory drugs.

These side effects vary from person to person, and not everyone will experience them. Regular check-ins with your doctor can help you manage these potential issues and decide if Lexapro is still the right choice for you.

Withdrawal Symptoms of Lexapro

If you stop taking Lexapro suddenly, you may experience withdrawal symptoms, also known as antidepressant discontinuation syndrome. These symptoms can range from mild to severe and may last for a few weeks. Common withdrawal symptoms include: 

• Dizziness: Feeling lightheaded or unsteady is one of the most common withdrawal effects.
• Headaches: Some people experience headaches as their body adjusts to being without the medication.
• Nausea: Stomach discomfort, including nausea or vomiting, can happen if Lexapro is stopped abruptly.
• Irritability or anxiety: You may feel unusually irritable or anxious, even if these weren’t symptoms you experienced before starting Lexapro.
• Brain zaps: Some people describe experiencing brain zaps, which feel like brief electric shocks in the brain. These are harmless but can be unpleasant.
• Sleep problems: Trouble falling asleep, staying asleep, or vivid dreams may occur when stopping Lexapro.

To avoid these withdrawal symptoms, taper off Lexapro gradually under your doctor’s supervision. Never stop taking it suddenly without consulting your healthcare provider.

How Lexapro Interacts with Alcohol & Other Pills

Lexapro can interact with alcohol and other medications, which may increase the risk of side effects or reduce the effectiveness of the treatment. 

Drinking alcohol while taking Lexapro can intensify side effects like drowsiness, dizziness, and impaired coordination. Alcohol is also a depressant, which can counteract the positive effects of Lexapro in treating depression and anxiety.

Lexapro can interact with various other drugs, including:

• Blood thinners like warfarin, which can increase the risk of bleeding.
• NSAIDs such as ibuprofen or aspirin, which also increase bleeding risks when combined with Lexapro.
• Other antidepressants or SSRIs, which may lead to a dangerous condition called serotonin syndrome, where there is too much serotonin in the brain. Symptoms include confusion, rapid heart rate, and sweating.

 Always inform your doctor about any medications, supplements, or herbal products you are taking to ensure there are no harmful interactions.

Addiction Risk Factors

Lexapro is not considered addictive, but there are some risks of dependence or misuse in certain cases. While it doesn’t create cravings or the euphoria associated with addictive substances, your body can develop physical dependence on it. This is why stopping Lexapro abruptly can lead to withdrawal symptoms.

Risk factors for dependence or misuse include:

• Long-term use: The longer you use Lexapro, the more your body becomes accustomed to it. Gradually tapering off is key to avoiding dependency issues.
• Underlying mental health conditions: If Lexapro is used to manage conditions like severe depression or anxiety, stopping the medication without proper guidance could lead to a relapse in symptoms.
• Misuse: Taking Lexapro in ways other than prescribed, such as higher doses, can lead to harmful effects, although this is rare.

If you feel that Lexapro is no longer working for you, or you’re concerned about dependence and addiction, talk to your doctor about other treatment options. They can help you find a plan that works best for your mental health while managing any risks.

Lexapro & Anti-Depressants | FAQs

What are some side effects of Lexapro?

Common side effects include nausea, dizziness, drowsiness, and dry mouth. Some people may also experience weight changes or sexual side effects. Most side effects are mild and go away over time.

Can I get addicted to antidepressants?

Antidepressants like Lexapro are not addictive in the way drugs like opioids or alcohol are. You won’t crave Lexapro, but your body may become dependent on it, which is why stopping suddenly can cause withdrawal symptoms.

What if my Lexapro stops working?

If Lexapro stops working, talk to your doctor. They may adjust your dose or suggest switching to a different medication to help manage your symptoms.

How can I safely stop using Lexapro?

To stop Lexapro safely, you should work with your doctor to gradually lower your dose. This helps prevent withdrawal symptoms and allows your body to adjust slowly. 

Get Compassionate Treatment & Addiction Recovery Help at Renaissance Recovery

Do you need help for yourself or a loved one misusing prescription drugs like Lexapro? If so, we can help at Renaissance Recovery. Our welcoming and inclusive rehabs in California and Florida offer outpatient treatment for all addictions and mental health conditions.

Every addiction to prescription medications is different, so all treatment plans at Renaissance are personalized to reflect this. Therapies may include:

• Motivational therapy
• Talk therapy
• MAT (medication-assisted treatment)
• Group therapy
• Family therapy
• Counseling
• Holistic therapy
• Aftercare

 Start your recovery right away by calling 866-330-9449.

Sources

[1] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6634816/

[2] https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10076339/

[3] https://www.sciencedirect.com/science/article/pii/S0014299919306843

[4] https://www.health.harvard.edu/blog/weighing-in-on-weight-gain-from-antidepressants-202408023063