Effexor (Venlafaxine) Withdrawal: Symptoms, Timeline, & Treatment

Effexor is the brand name for the drug Venlafaxine—a commonly prescribed antidepressant that helps people manage symptoms of depression and anxiety. However, stopping Effexor (especially if done so abruptly) can lead to withdrawal symptoms. 

In this article, we will cover Effexor withdrawal symptoms, Effexor withdrawal side effects, and the expected timeline. You will also discover helpful coping strategies and treatment options to navigate this challenging process safely.

What is Effexor?

Effexor is an SNRI antidepressant, meaning it stops the reuptake of serotonin and norepinephrine [2]. This leads to an influx of serotonin and norepinephrine in the body. These two neurochemicals are responsible for mood regulation, focus, appetite, and even things like heart rate, blood sugar levels, and metabolism are all impacted by these hormone levels. The SNRI makes it possible for those with depression to balance these hormone levels and alleviate depression symptoms. 

An antidepressant like Effexor is used primarily for major depressive disorder,  generalized anxiety disorder, and social phobia. However, some physicians will prescribe Effexor for off-labeled uses, including obsessive-compulsive disorder, nerve pain, and chronic pain syndromes [1].

Effexor Withdrawal Symptoms

Withdrawal symptoms of Effexor can vary significantly from person to person depending on factors such as the drug dosage, duration of use, and individual physiology and genetics. Common Effexor withdrawal symptoms include:

Physical Symptoms:

• Dizziness
• Dry mouth
• Fatigue
• Impaired coordination
• Nausea and vomiting
• Diarrhea
• Headaches
• Sweating and tremors
• Flu-like symptoms

Neurological Symptoms:

• Brain zaps (sudden shock-like sensations in the brain)
• Sensory disturbances (ex: light sensitivity)
• Sleep isues (nightmares, insomnia, somnolence) [2]
• Difficulty concentrating

Psychological Symptoms:

• Anxiety
• Irritability and agitation
• Mood swings
• Depression
• In some severe cases, anorexia and dysphoric mood [2]

These Effexor withdrawal side effects can range from mild to severe, depending on the withdrawal process.

Effexor Withdrawal Timeline

The venlafaxine withdrawal timeline can be divided into several phases. Understanding this timeline can help set expectations for your recovery.

1. Initial Phase (Days 1-2):
   • Withdrawal symptoms often begin within 24-48 hours after the last dose.
   • Symptoms like headaches, dizziness, feeling sick, and fatigue are most prominent during this time as your body tries to adjust without the medication.
2. Peak Phase (Days 3-7)
   • Symptoms may intensify and reach their peak in this first week without Effexor.
   • Physical and emotional symptoms intensify, often resembling the flu, with sweating, shaking, nausea, increased anxiety, irritability, and mood swings.
3. Post Peak Phase (Weeks 1-2)
   • Typically, the worst symptoms have already occurred, and gradual recovery begins. 
   • Individuals may still experience psychological effects and sleep disturbances like insomnia or nightmares.
4. Recovery Phase (Week 3 and beyond):
   • For most, Effexor withdrawal symptoms clear up within a month, though full recovery may take up to six months
   • Those with prolonged symptoms like anxiety or other mood stability issues may benefit from continued medical and therapeutic support.

Medical guidance is crucial for managing Effexor withdrawal safely, as symptoms and their duration can vary widely based on individual circumstances and health factors. Your prescribing doctor can create a personalized tapering schedule to minimize discomfort and provide support throughout the withdrawal process. 

Coping with Effexor (Venlafaxine) Withdrawal Symptoms

Effexor withdrawals can be physically and emotionally taxing, but there are ways to manage the symptoms effectively. Below are tips on how to wean off Effexor and cope with withdrawal symptoms:

1. Tapering Off:
   • Gradually reducing your dose under medical supervision is the safest way to discontinue Effexor. Talk to your doctor about a tapering schedule specific to your needs, ensuring a smoother transition. Remember that breaking pills in half or trying to self-adjust your dosage is not an ideal solution. Your doctor will prescribe precise milligram reduction for the most effective tapering schedule. 
2. Maintain a Healthy Lifestyle:
   • A healthy lifestyle is the best support you can give your body when facing the challenges of Effexor withdrawal. Prioritize a balanced diet rich in vitamins. Stay hydrated to alleviate physical symptoms such as headaches and fatigue. Regular physical activity can boost your mood and reduce the discomfort of withdrawal symptoms.
3. Use Antihistamines:
   • Everyday medications, including antihistamines, may help alleviate withdrawal symptoms like nausea, headaches, or trouble sleeping. These over-the-counter remedies can provide relief for some individuals, but it is important to consult a doctor before using them.
4. Seek Emotional Support:
   • Consider therapy or counseling to address psychological withdrawal symptoms like anxiety and mood swings. Keep your family and friends in the loop, letting them know this withdrawal period from Effexor may require their added support and patience. 
5. Practice Relaxation Techniques:
   • Incorporate mindfulness, meditation, or yoga into your daily routine to manage stress and improve focus. Even holistic therapies like acupuncture, massages, and spa days can be beneficial during your low moments of physical and psychological side effects. 

Effexor Withdrawal Treatment

If Effexor withdrawal symptoms become overwhelming, medical treatment options are available to ease the process. Here are some effective approaches:

Medication Management

Although Effexor is a generally safe antidepressant, it may not be the best fit for everyone due to individual genetic and personal factors. A doctor may prescribe a different antidepressant with a longer half-life to bridge the gap and minimize withdrawal symptoms. 

Aside from other antidepressants, medication management may involve benzodiazepines or antihistamines, which are often used to help with specific symptoms, such as insomnia or anxiety. 

Therapy

Cognitive Behavioral Therapy (CBT) can address underlying mental health concerns that resurface during withdrawal. CBT can help individuals reframe negative thought patterns and develop more constructive coping strategies. Talk therapy can also equip coping mechanisms to manage symptoms as they arise. 

Holistic Approaches

The benefits of holistic approaches include promoting relaxation, reducing stress, and supporting overall well-being during the withdrawal process. Practices like acupuncture, massage therapy, breath work, and herbal supplements (with medical guidance) can alleviate physical discomfort and encourage emotional balance and awareness. 

Inpatient or Outpatient Care:

For many withdrawal cases, seeking professional treatment at a rehab or detox center may be necessary. Whether through the structured support of inpatient rehab, which provides 24/7 medical care and supervision, or the accountability of outpatient treatment, these approaches can serve as a catalyst for lasting change and freedom from addiction.

Medical Monitoring:

Regular check-ins with a healthcare provider may be beneficial as you manage withdrawal symptoms and prevent complications. This monitoring often includes assessments of physical and emotional health, adjustments to any prescribed medications, and ongoing guidance to help individuals navigate the withdrawal process safely and effectively. 

Effexor withdrawal side effects can be uncomfortable and discouraging. However, proper support can minimize adverse effects, keeping you safe and supported during this vulnerable adjustment period. 

FAQs | Effexor (Venlafaxine) Withdrawal

How long does Effexor withdrawal last?

Effexor withdrawal typically lasts a few weeks to several months. The severity and duration depend on the dosage, how long you’ve taken the medication, and individual differences in how the body processes the drug. While most people recover after a few weeks, some may experience lingering symptoms that require additional medical or therapeutic support.

Do antihistamines help with Effexor withdrawal?

Yes, antihistamines can help manage certain symptoms, such as nausea, dizziness, and insomnia. While they can provide temporary relief, they are a short-term solution and should not replace medical supervision or a comprehensive withdrawal plan. Always consult your doctor before using antihistamines to ensure they are appropriate for your situation.

What are venlafaxine brain zaps?

Brain zaps are sudden, electrical shock-like sensations in the brain, often described as disorienting and uncomfortable. They are somewhat unique to venlafaxine withdrawal and typically resolve over time as the body adjusts. Staying hydrated, getting adequate rest, and following a tapering schedule can reduce their intensity and frequency.

How to stop taking venlafaxine 75 mg?

To stop taking venlafaxine 75 mg safely, consult your doctor to create a gradual tapering plan tailored to your needs. Abrupt discontinuation can lead to severe withdrawal symptoms. The key to minimizing discomfort is a slow reduction in dosage. Your doctor may also recommend additional strategies or medications to support this process.

Find Compassionate Care for Effexor Withdrawal at a World-Class Rehab 

Effexor withdrawal is rarely life-threatening. However, abrupt discontinuation can lead to severe symptoms, such as anxiety, confusion, and uncomfortable physical side effects. These risks may cause individuals to avoid going off of their antidepressants. While Effexor is not classified as an addictive substance, psychological addiction to prescription medication is possible. 

If you need help tackling prescription addiction or adverse withdrawal, reach out to Renaissance Recovery today. We can connect you with medical detox centers and support to help you withdraw safely and more comfortably.

With Renaissance’s help, you can move into ongoing treatment at one of our luxury rehabs in Florida or California. Our outpatient treatment programs enable you to continue living at home while getting person-first treatment during weekday sessions. 

Every addiction is unique, so all our treatment plans reflect this. Therapies may include:

• Counseling
• Holistic treatments
• Motivational therapies
• Psychotherapies
• Group therapy
• Family therapy
• Medication-assisted treatment
• Aftercare planning

When you’re ready to overcome prescription addiction, call 866-330-9449 for immediate assistance.

Sources

[1] https://www.mayoclinic.org/diseases-conditions/depression/in-depth/antidepressants/art-20044970

[2] https://pmc.ncbi.nlm.nih.gov/articles/PMC1681629/