Dexedrine (Dextroamphetamine) Withdrawal: Quitting, Symptoms, Timeline, & Help

Dexedrine, a prescription stimulant used to treat narcolepsy and ADHD (attention deficit hyperactivity disorder), is effective when taken as prescribed. Any form of Dexedrine abuse, though, can lead to dependence, addiction, and a cycle that’s challenging to escape.

Withdrawal from Dexedrine occurs when someone dependent on the drug stops using it. This is an experience marked by physical discomfort, emotional turmoil, and intense cravings. This page explores what to expect from the Dexedrine withdrawal process, from the symptoms and timeline to effective, evidence-based treatments.

What is Dexedrine Used For?

Dexedrine is a prescription medication containing dextroamphetamine, a stimulant that affects the CNS (central nervous system). It’s mainly used to treat ADHD and narcolepsy [1]. For ADHD, Dexedrine helps improve focus, reduce impulsivity, and manage hyperactivity. For those with narcolepsy, the medication helps regulate sleep patterns by promoting wakefulness during the day.

Dexedrine increases neurotransmitters in the brain, including dopamine and norepinephrine [2]. These chemicals govern attention, motivation, and energy regulation. When used as prescribed and monitored by a healthcare professional, Dexedrine can be an effective tool for managing the symptoms of these conditions.

That said, the stimulant properties of the medication make it prone to misuse. Some people take Dexedrine to boost energy, stay awake longer, or enhance performance, particularly in academic or workplace settings. Misuse can lead to tolerance, dependence, and addiction, making this medication potentially problematic. For this reason, Dexedrine is a controlled substance in the United States.

Effects of Dextroamphetamine

Dexedrine’s effects can vary depending on how it’s used. When taken as indicated, it improves concentration, increases alertness, and reduces fatigue for individuals with ADHD or narcolepsy. These therapeutic benefits can make daily life much more manageable. However, Dexedrine side effects may occur, even when the drug is taken as prescribed. These may include:

• Insomnia
• Reduced appetite
• Dry mouth
• Increased heart rate
• Anxiety
• Nervousness

When misused or taken in high doses, the effects of Dexedrine become more pronounced and dangerous. Misuse can trigger euphoria, heightened energy, and increased self-confidence, which are some of the reasons people may abuse the drug. Over time, repeated misuse changes how the brain responds to dopamine, which makes pleasure without the drug challenging [3].

Long-term misuse of Dexedrine can cause serious physical and psychological problems, such as:

• High blood pressure
• Cardiovascular complications
• Paranoia
• Hallucinations
• Severe mood swings
• Aggression
• Risk of addiction and Dexedrine overdose

Dexedrine should be used only as prescribed. Seek immediate help if misuse or dependence develops.

Dextroamphetamine Withdrawal Symptoms

When someone stops using Dexedrine after prolonged or heavy use, the body and brain struggle to adjust to the absence of the drug. This adjustment period is known as Dexedrine withdrawal, and it can trigger an array of intensely uncomfortable symptoms. The most common symptoms of Dexedrine withdrawal include:

• Fatigue: A sudden drop in energy is one of the first and most noticeable signs of Dexedrine withdrawal.
• Depression: Many individuals experience a crash, marked by intense sadness, hopelessness, or lack of interest in daily activities.
• Irritability and mood swings: Emotional instability, including frustration or anger, is common during detox from Dexedrine.
• Intense cravings: A powerful desire to use Dexedrine again can lead to relapse before recovery gains traction.
• Sleep disturbances: Insomnia or excessive sleeping (hypersomnia) may occur during withdrawal from Dexedrine.
• Increased appetite: Dexedrine often suppresses hunger so withdrawal can lead to overeating and weight gain.
• Cognitive difficulties: People may struggle to concentrate, think clearly, or make decisions during withdrawal.

In severe cases, amphetamine/dextroamphetamine withdrawal may also cause:

• Paranoia or psychosis: Rare but possible, especially if psychotic symptoms were present during Dexedrine misuse [4].
• Physical symptoms: Muscle aches, headaches, and tremors can occur as the body adjusts.

The severity and duration of the symptoms of Dexedrine withdrawal depend on the length of use, dosage, and individual health. Withdrawal is uncomfortable but manageable, especially with the proper support and guidance.

How Long Does Dextroamphetamine Withdrawal Last?

The timeline for Dexedrine withdrawal varies from person to person, but the process generally unfolds in three phases:

Crash phase (First 1 to 2 Days)

Symptoms include extreme fatigue, depression, and increased appetite. During this phase, the body reacts to the sudden absence of Dexedrine, leading to a significant drop in energy and mood.

Acute withdrawal phase (next 1 to 2 weeks)

Symptoms include cravings, mood swings, irritability, sleep disturbances, and difficulty concentrating. This is the most challenging phase, as psychological symptoms like cravings and depression peak. Support and coping strategies help streamline this phase of Dexedrine withdrawal.

Prolonged withdrawal phase (weeks to months)

Symptoms include lingering cravings, mood instability, and low motivation. While most physical symptoms subside, emotional and psychological symptoms may persist for weeks or months.

The following factors influence the length of Dexedrine withdrawal:

• Dosage and duration: Higher doses and longer use typically lead to more severe dexedrine withdrawal symptoms.
• Individual health: A person’s metabolism, age, and overall health can affect recovery speed.
• Co-occurring conditions: Mental health disorders like anxiety or depression can prolong the withdrawal process.

Although Dexedrine withdrawal can be difficult, symptoms will improve over time, especially with proper care and treatment. Seeking professional help can significantly ease the process and reduce the risk of relapse.

Are There Any Home Remedies for Getting Clean Safely?

While professional support is strongly recommended when withdrawing from stimulants like Dexedrine, some people may consider starting the process at home. However, managing withdrawal symptoms alone can be challenging and potentially unsafe.

If you are considering detoxing from Dexedrine at home, these strategies may help alleviate some withdrawal symptoms and support your body through the process:

• Stay hydrated: Dexedrine withdrawal can provoke dehydration, especially if symptoms like sweating or vomiting occur. Drinking water and electrolyte-rich fluids can help your body maintain balance and energy.
• Eat nutrient-rich foods: Your body will need extra nutrients to heal. Focus on eating balanced meals with lean proteins, whole grains, fruits, and vegetables. Avoid processed foods and sugary snacks, which can worsen mood swings.
• Create a restful environment: Fatigue and sleep disturbances are common during withdrawal. Set up a quiet, dark space for relaxation. Using white noise machines or soothing music can improve sleep quality.
• Engage in light physical activity:  Exercise can boost endorphins and improve mood [5]. Light activities like walking or stretching may help reduce irritability and anxiety. Avoid intense exercise during the early stages of withdrawal, as it could strain your body.
• Use stress-relief techniques: Mindfulness practices like deep breathing, meditation, or yoga can help you manage emotional symptoms such as anxiety and irritability.
• Stay busy with healthy distractions: Keeping your mind occupied can reduce the intensity of cravings. Try activities like journaling, painting, or watching uplifting movies.

While these remedies can help ease symptoms, they are not substitutes for professional care. Detoxing at home may not address more profound psychological challenges or the potential for severe withdrawal symptoms like paranoia or psychosis. Without medical supervision, there’s a higher risk of relapse or complications.

If you experience any of the following, seek immediate medical attention:

• Severe depression or suicidal thoughts.
• Psychotic symptoms such as hallucinations or paranoia.
• Signs of dehydration, such as dark urine or dizziness.
• Inability to manage cravings or withdrawal symptoms on your own.

Medications and Dextroamphetamine Withdrawal

While there are no medications specifically designed to treat Dexedrine withdrawal, some may help manage symptoms and make the detox process more bearable. These include:

• Antidepressants: Withdrawal often causes depression and anxiety as the brain adjusts to the absence of Dexedrine. Antidepressants, such as SSRIs or SNRIs, can help stabilize mood and reduce emotional discomfort.
• Sleep aids: Insomnia or sleep disturbances are common during Dexedrine withdrawal. Non-addictive sleep aids, such as melatonin or trazodone, may be used to promote restful sleep.
• Anti-anxiety medications: Medications like hydroxyzine or buspirone can help alleviate anxiety without the risk of addiction associated with benzodiazepines.
• Appetite stimulants: Increased hunger is common during Dexedrine withdrawal, but some individuals may experience a lack of appetite. In such cases, medications like cyproheptadine can help regulate eating patterns.

In rare cases, individuals may experience severe symptoms such as psychosis or hallucinations. Antipsychotic medications may be used temporarily to manage these conditions.

Medications are not a cure for addiction, but they can play a key role in stabilizing individuals during withdrawal. By managing the physical and psychological symptoms, these treatments help people focus on the next steps in recovery, such as therapy and lifestyle changes.

Self-medicating during withdrawal is risky and can lead to further complications. Taking medications without medical supervision increases the likelihood of side effects, misuse, or interactions with other substances. Always consult a healthcare professional before using any medicines during Dexedrine withdrawal.

While medications can address immediate symptoms, long-term recovery requires a comprehensive approach. Behavioral therapies, support groups, and healthy lifestyle changes are central to addressing the root causes of addiction and preventing relapse. Combining medical support with treatment and ongoing care offers the best chance for a successful and lasting recovery.

Get Help with Dexedrine Detox and Addiction Treatment at a Premier Rehab

If you or a loved one needs help combating Dexedrine addiction, reach out to Renaissance Recovery. We can connect you with detox centers near you to help streamline the side effects of Dexedrine withdrawal and prepare you for ongoing treatment at one of our luxury rehabs in California or Florida.

When you choose a Renaissance outpatient program, you can continue living at home and fulfilling your daily commitments while engaging in compassionate treatment for stimulant addiction.

All addictions are unique, and all our treatment plans are personalized to reflect this. Therapies might include:

• Medication management
• Counseling
• Motivational therapies
• Talk therapies
• Family therapy
• Holistic treatments
• Group therapy
• Aftercare planning

Begin your recovery immediately by calling 866-330-9449.

Sources

[1] https://www.ncbi.nlm.nih.gov/books/NBK556103/

[2] https://scholarspace.jccc.edu/cgi/viewcontent.cgi?article=1021&context=honors_journal

[3] https://www.ncbi.nlm.nih.gov/books/NBK576548/

[4] https://www.ncbi.nlm.nih.gov/books/NBK576550/

[5] https://www.health.harvard.edu/staying-healthy/exercising-to-relax