All About the E 404 Orange Pill: Uses, Side Effects, & More

The E 404 orange pill is a commonly prescribed medication easily identifiable by its round orange shape and distinct imprint. Containing amphetamine and dextroamphetamine, it’s mainly used to manage ADHD and narcolepsy. These conditions can significantly affect daily life, making focus, alertness, and productivity difficult 

While the E 404 pill can be life-changing for those who need it, the medication is a controlled substance that can be dangerous if misused. This page explores how the E 404 orange pill works, its potential side effects, and the risks associated with misuse.

What Is the E 404 Orange Pill?

The E 404 orange pill is a prescription medication used to treat ADHD (attention deficit hyperactivity disorder) and narcolepsy [1]. Its distinctive round, orange design with the imprint E 404 makes it easy to identify. This combination medication contains amphetamine and dextroamphetamine, both CNS (central nervous system) stimulants. These stimulants help improve focus, control impulsive behaviors, and promote wakefulness.

The pill is available only by prescription and is classified as a Schedule II controlled substance due to its potential for misuse and addiction [2]. Like all drugs in this class, the E 404 pill should be used as directed and under the supervision of a doctor. 

Amphetamine and Dextroamphetamine

Amphetamine and dextroamphetamine are the active ingredients in the E 404 pill. They work together to increase the levels of neurotransmitters in the brain like norepinephrine and dopamine [3]. This helps improve concentration, reduce hyperactivity, and enhance overall alertness in those using the medication. 

This combination of medications has been widely studied and is considered effective for ADHD and narcolepsy treatment. Misuse or overuse of these drugs can lead to serious health problems, including dependence and addiction. 

E 404 Orange Pill vs. Adderall: Is It the Same Thing?

When comparing the E404 orange pill vs Adderall, they are essentially the same. The Adderall round orange pill is a branded formulation of amphetamine-dextroamphetamine, while the E 404 orange pill is a generic version of the same combination medication. Both contain the same active ingredients and deliver the same effects when taken in equivalent doses. 

Images of Adderall Round Orange Pill

The E 404 pill has a distinct appearance that helps individuals and healthcare providers identify it. It is small, round, and orange, with E 404 imprinted on one side. This design ensures it is not confused with other medications. 

Other versions of amphetamine and dextroamphetamine pills, including generic Adderall, may come in various shapes, sizes, and colors: 

Some are oval or oblong rather than round.

Colors range from peach to beige, depending on the dosage and manufacturer.

Imprints such as U31 or 30 are commonly seen on similar medications. 

If you are uncertain about the appearance of a pill, use a trusted pill identifier tool or consult your pharmacist to confirm it matches your prescription. Identifying the pill correctly ensures safety and prevents accidental misuse.

Drug Class

The E 404 pill belongs to the drug class known as CNS stimulants. These medications are designed to increase activity in certain parts of the brain and central nervous system, improving focus, alertness, and energy levels. 

CNS stimulants are commonly indicated to treat conditions like ADHD and narcolepsy. These drugs may also be beneficial for some people with treatment-resistant depression. While they are highly effective, they carry risks which include dependence, addiction, and overdose.

Common Uses

The E 404 orange pill is chiefly prescribed for two conditions:

1. ADHD: ADHD is a condition that affects children and adults. Symptoms include difficulty paying attention, hyperactivity, and impulsivity. The E 404 pill helps manage these symptoms by improving focus and self-control. Many individuals with ADHD find that the medication enables them to stay organized, complete tasks, and feel less overwhelmed.
2. Narcolepsy: Narcolepsy is a sleep disorder characterized by extreme daytime sleepiness and sudden sleep attacks. The E 404 pill helps people with narcolepsy stay awake and alert throughout the day. By promoting wakefulness, the medication significantly improves the quality of life for those with this condition. 

The E 404 pill is sometimes used off-label for conditions like severe fatigue or as part of a treatment plan for depression when other options have not worked [4]. These uses are at the discretion of a healthcare provider and depend on individual needs. 

Side Effects of Taking the E 404 Pill

Like all medications, the E 404 orange pill can cause side effects. While many people tolerate it well, others may experience uncomfortable or serious reactions. Understanding these side effects can help you use the medication safely and identify when to seek medical attention. 

Common Side Effects

E 404 pills contain amphetamine and dextroamphetamine, substances that can trigger mild side effects. These effects usually lessen as your body adjusts to the medication. Consult your physician if side effects persist, worsen, or become intolerable. The most common side effects associated with this drug include:

• Insomnia: Difficulty falling or staying asleep is a frequent complaint among those using the medication. This is due to the pill’s stimulant effect, which encourages wakefulness.
• Loss of appetite: The E 404 orange pill can suppress hunger, leading to reduced food intake and potential weight loss.
• Dry mouth: Many people report a feeling of dryness in their mouth, which can be relieved by drinking more water.
• Headache: Some individuals experience headaches, especially during the first few weeks of treatment.
• Nervousness: The stimulating effects may cause restlessness or feelings of anxiety.
• Increased heart rate: A faster-than-normal heartbeat can occur as a result of the medication’s effects on the central nervous system.

Most people find these side effects manageable. Monitor side effects when taking the medication—your doctor can adjust your dosage or suggest ways to minimize discomfort if needed. 

Serious Side Effects

Although rare, serious side effects may manifest in some people taking the E 404 pill. These reactions require immediate medical attention, as they may indicate a potentially dangerous issue. Serious side effects associated with amphetamine-dextroamphetamine include:

• Cardiovascular complications: Symptoms like chest pain, shortness of brain, or fainting could signal heart problems. High blood pressure or irregular heartbeats may also develop, especially in individuals with pre-existing conditions.
• Mental health changes: Sudden mood swings, increased aggression, or severe anxiety could be signs of a negative reaction to the medication. Some individuals report hallucinations or paranoia, although this is rare.
• Severe allergic reactions: Swelling of the face, throat, or tongue, along with difficulty breathing, could indicate a life-threatening allergic reaction. Hives or severe skin rashes are also warning signs.
• Circulation issues: This medication may cause poor blood flow, resulting in pain, numbness, or skin color changes in fingers or toes—a condition known as Raynaud’s phenomenon [5].
• Dependence and withdrawal:  Long-term or misuse of the E 404 pill can lead to the development of physical and psychological dependence. Sudden discontinuation may trigger withdrawal symptoms like depression, fatigue, and difficulty concentrating. 

If you notice any of these serious side effects, stop taking the medication and contact a healthcare provider immediately. In extreme cases, do not hesitate to seek medical care—it could save a life.

To minimize risks when taking this medication: 

• Always follow your doctor’s instructions regarding dosage and timing.
• Avoid combining the medication with alcohol or other substances unless approved by your doctor.
• Inform your healthcare provider about any pre-existing conditions, especially heart problems, mental health concerns, or allergies. 

By learning as much as possible about the potential side effects, you can use the E 404 pill responsibly and reduce the likelihood of serious or life-threatening complications. 

Dangers of Taking the E 404 Pill

While the E 404 pill can be highly effective for managing ADH and narcolepsy, it also comes with major risks. Improper use or misuse can provoke severe adverse outcomes, including harmful interactions, dependence, and fatal overdose.

Interactions With Other Substances

Taking the E 404 pill alongside some other substances can cause dangerous interactions. These can either amplify the medication’s effects, increase the risk of side effects, or diminish its effectiveness. Substances to watch out for when taking amphetamine-dextroamphetamine include: 

• Other stimulants: Combining the E 404 pill with nicotine, caffeine, or other stimulants can overstimulate the central nervous system. This may lead to an increased heart rate, high blood pressure, or anxiety.
• Alcohol: Mixing the pill with alcohol can mask intoxication, leading some people to drink more than they should. This increases the risk of alcohol poisoning and impairs judgment.
• Antidepressants: Some antidepressants, especially MAOIs (monoamine oxidase inhibitors), can cause severe reactions when combined with the E 404 pill. This includes dangerously high blood pressure or serotonin syndrome, a life-threatening condition [6].
• OTC medications: Some cold medicines, such as decongestants, may also contain stimulants that interact with the pill, inflaming side effects like insomnia or elevated heart rate. 

Inform your doctor of all supplements, medications, and substances you take before starting treatment with the E 404 pill. This can help mitigate adverse reactions, harmful complications, and dependence or addiction. 

Misusing Adderall & Addiction Risk Factors

The E 404 pill, as a generic form of Adderall, has a strong potential for misuse. Some people take it without a prescription to enhance focus, stay awake longer, or improve academic or work performance. That said, misuse carries serious risks, including: 

• Physical dependence: The body can adapt to stimulants over time, requiring higher doses to achieve the initial effects. As tolerance builds, increasing dosage or frequency can accelerate the development of dependence.
• Addiction: The drug affects the brain’s reward system, creating a craving for its effects. Addiction is a chronic condition that disrupts all areas of life. It’s a progressive disorder that responds favorably to treatment.
• Health consequences: Misusing the medication increases the risk of cardiovascular problems, mental health issues, and overdose.
• Withdrawal symptoms: Stopping the drug abruptly after extended use can cause fatigue, depression, and difficulty concentrating, making it hard to quit without medical intervention. 

Risk factors for addiction include a history of substance abuse, taking higher-than-prescribed doses, or using the drug recreationally.

Precautions

Using the E 404 pill safely requires the following precautions: 

• Only take as prescribed: Never take the medication without a prescription or share it with others. The dosage is tailored to individual needs, and misuse can have dangerous consequences.
• Disclose your medical history: Inform your doctor about any conditions such as heart disease, high blood pressure, or mental health issues like depression or anxiety. These conditions can increase the risks associated with the pill.
• Monitor for side effects: Keep track of how your body reacts to the medication and report any unusual symptoms to your doctor immediately.
• Avoid during pregnancy: The E 404 pill falls under Pregnancy Category C, meaning it may harm an unborn baby. Women who are pregnant or planning to become pregnant should discuss alternatives with their doctor.
• Store safely: Keep the medication out of reach of children and others who might misuse it. 

Taking these precautions can minimize risks and ensure the medication is as effective and safe as possible. 

Overdose

An overdose of the E 404 pill can occur when someone takes more than the prescribed dose or combines it with other harmful substances. Overdoses are medical emergencies and require immediate attention. 

Symptoms of an overdose on the E 404 orange pill include:

• Severe confusion or agitation
• Rapid or irregular heartbeat
• High fever
• Hallucinations
• Loss of consciousness
• Seizures 

In extreme cases, overdose on amphetamine-dextroamphetamine can lead to heart attack, stroke, or death. If you suspect an overdose, call emergency services immediately. While waiting for help, try to provide information about the amount taken and any other substances involved. Quick medical intervention can save lives.

Get Science-Backed, Insurance-Covered Addiction Treatment at Renaissance Recovery

If you need help getting back on track from stimulant misuse, contact Renaissance Recovery. We treat addictions and mental health issues in an outpatient setting at our rehabs in California and Florida. 

Our outpatient programs offer support, structure, and flexibility, helping you address stimulant addiction with personalized treatments, such as:

• Group therapy
• Family therapy
• Medication management
• Counseling
• Talk therapies
• Motivational therapies
• Holistic therapies
• Aftercare

Start addressing stimulant misuse by calling 866-330-9449. 

Sources 

[1] https://medlineplus.gov/druginfo/meds/a601234.html

[2] https://www.deadiversion.usdoj.gov/schedules/schedules.html 

[3] https://www.ncbi.nlm.nih.gov/books/NBK507808/ 

[4] https://pmc.ncbi.nlm.nih.gov/articles/PMC3181580/ 

[5] https://www.arthritis.org/drug-guide/medication-topics/medications-can-cause-raynauds

[6] https://pmc.ncbi.nlm.nih.gov/articles/PMC6734608/