Buspirone Withdrawal Symptoms, Timeline, & Treatment

Buspirone is a medication commonly prescribed for anxiety that’s provided relief for countless individuals by helping them manage overwhelming thoughts and feelings. What happens when it’s time to stop using buspirone, though?

While the medication is not addictive and has a lower risk of dependence than other anti-anxiety medications, discontinuing it can still trigger challenges. Some people may experience buspirone withdrawal symptoms or find it difficult to transition off the drug without professional oversight.

This guide shows you how to stop taking buspirone safely and manage buspirone withdrawal symptoms. You’ll also discover how to get ongoing treatment for anxiety. 

What is Buspirone?

Buspirone is widely used to treat GAD (generalized anxiety disorder). The medication, often marketed as Buspar, was discontinued due to the availability of generic forms, not for safety reasons [1]. Unlike benzodiazepines, which are also commonly used to manage anxiety, buspirone is non-sedative and has a much lower risk of dependence [2]. This makes it a preferred option for individuals seeking long-term solutions for anxiety without the challenges of addiction or severe withdrawal symptoms.

The medication affects serotonin and dopamine receptors in the brain. These neurotransmitters regulate mood, anxiety, and emotional well-being. By altering their activity, buspirone helps create a sense of calm and reduces excessive worry.

Typically taken in tablet form, buspirone is prescribed in doses ranging from 15 to 60mg daily, depending on the severity of symptoms and individual needs. In addition to its primary use for GAD, research suggests buspirone may be effective in treating conditions like depression, social anxiety, and specific symptoms of Parkinson’s disease [3].

Despite its benefits, buspirone is not free from complications. Abruptly discontinuing the medication can disrupt the brain’s balance of neurotransmitters, leading to Buspar withdrawal symptoms in some people.

Risks of Buspirone Withdrawal

Buspirone is acknowledged to be a safer alternative to other anxiety medications due to its low potential for physical dependence and withdrawal. Unlike drugs like Xanax or Valium, which directly impact GABA receptors in the brain, buspirone works on serotonin receptors. This difference in mechanism of action dramatically reduces the likelihood of dependence and addiction.

That said, abruptly stopping buspirone can prompt withdrawal effects, especially in those who have taken the medication for an extended period or at higher doses. These Buspar withdrawal symptoms are less about addiction and more about the brain’s adjustment to the absence of the drug.

One of the primary risks of Buspar withdrawal is the possibility of confusing side effects like a relapse of the original anxiety disorder. This can cause frustration or fear, leading some people to restart the medication unnecessarily.

Another potential risk involves interactions with other medications or substances. People taking drugs that influence serotonin levels, such as antidepressants, may experience more pronounced symptoms of Buspar withdrawal. Additionally, those with pre-existing health conditions—liver or kidney issues, for instance—may face complications when stopping buspirone.

To mitigate these risks, healthcare providers recommend a gradual reduction in dosage rather than an abrupt cessation. A Buspar taper helps the brain adapt slowly, minimizing discomfort and ensuring a smoother transition.

Buspirone Withdrawal Symptoms

While the symptoms of Buspar withdrawal are generally milder than those associated with other anxiety medications, they can still be uncomfortable for some people. These symptoms occur as the brain adjusts to the absence of the drug, which has been regulating neurotransmitter activity.

Common symptoms of Buspar withdrawal include:

• Increased anxiety
• Restlessness
• Irritability
• Mood swings
• Dizziness and lightheadedness
• Muscle tension and stiffness
• Nausea and GI issues
• Insomnia and vivid dreams
• Tingling in the hands or feet
• Fatigue
• Sweating or changes in body temperature

In rare cases, individuals may experience severe symptoms such as fainting, chest pain, or severe mood changes. If any of these Buspar withdrawal symptoms occur, seek immediate medical attention.

Symptoms of Buspar withdrawal may mimic the original anxiety symptoms for which the medication was prescribed. Distinguishing between the two can be challenging without professional guidance. This is much less likely to happen than with anxiety medications like benzodiazepines, though.

Who is most likely to experience Buspirone Withdrawal Symptoms?

Not everyone who discontinues buspirone will experience withdrawal symptoms, but certain factors can raise the risk. These include:

• High dosage: Individuals taking larger doses of buspirone may experience more pronounced withdrawal effects due to the greater influence the medication has on their brain chemistry.
• Long-term use: The longer someone uses buspirone, the more accustomed their brain becomes to its presence. This adaptation can make symptoms of Buspar withdrawal more likely.
• Pre-existing health conditions: People with liver or kidney issues may metabolize buspirone more slowly, prolonging withdrawal.
• Older age: Age-related changes in metabolism can increase the duration and intensity of withdrawal symptoms.
• Concurrent medications: Drugs that interact with serotonin or buspirone metabolism can complicate withdrawal.

For individuals with any of these risk factors, working closely with a healthcare provider to develop a personalized discontinuation plan is the optimum pathway to discontinuation.

How long do Buspirone Withdrawal Symptoms last?

The duration of buspirone withdrawal symptoms varies from person to person, depending on dosage, length of use, and overall health. This is a typical buspirone withdrawal timeline:

• 0 to 48 hours: As buspirone has a short half-life of 2 to 3 hours, initial symptoms such as mild anxiety, dizziness, or nausea may appear shortly after the last dose.
• 3 to 7 days: Symptoms of Buspar withdrawal typically peak during this period, with individuals experiencing heightened anxiety, restlessness, or physical discomfort.
• For most people, 1 to 4 weeks: Symptoms gradually subside within a month. However, those who used buspirone for an extended period or at high doses may take longer to feel fully adjusted.

If symptoms like anxiety or insomnia persist beyond the initial withdrawal period, it may indicate a return of the original condition rather than ongoing withdrawal effects [4], although this is highly unlikely to happen.

How do I safely quit Buspirone?

Here’s how to taper off buspirone safely:

• Consult your healthcare provider: Always start by discussing your decision with a doctor. They can evaluate your unique situation and recommend a tapering plan that suits your needs.
• Taper the dose gradually: A slow reduction in dosage allows your brain to adjust to lower levels of the medication. For example, your doctor might recommend decreasing your dose by 5 to 10 mg weekly until you no longer take it.
• Monitor for symptoms: Keep a journal to track any physical or emotional changes during tapering. This record can help your doctor make adjustments to your plan if needed.
• Support your body: Proper hydration supports overall health and alleviates some symptoms of Buspar withdrawal. Nutrient-rich foods can improve energy levels and mood. Physical activity can help reduce anxiety and promote better sleep.
• Consider therapy: Engaging in CBT (cognitive behavioral therapy) or other forms of counseling can provide support for managing any lingering anxiety or emotional challenges.
• Lean on support networks: Friends, family, or support groups can offer encouragement and understanding as you transition off buspirone.

With the right plan and resources, quitting buspirone can be manageable. Remember, your healthcare provider is there to guide you every step of the way.

FAQs

How long do withdrawal symptoms from buspirone last?

The symptoms of buspirone withdrawal typically last between 1 and 4 weeks, depending on factors like dosage, duration of use, and individual health. Most symptoms peak within the first week and gradually subside. For some, lingering effects may take longer to resolve and benefit from ongoing treatment. 

What happens if you skip a day of buspirone?

Missing a single dose of buspirone may cause mild symptoms, such as increased anxiety or dizziness. If you miss a dose, take it when you remember unless it’s close to your next dose. Avoid doubling up to compensate for the missed medication.

Do buspirone side effects go away?

Most side effects of buspirone, such as nausea or dizziness, improve as your body adjusts to the medication. This adjustment period typically lasts a few days to a few weeks. If side effects persist or worsen, consult your healthcare provider.

Does buspirone have permanent effects?

Buspirone is not known to cause permanent effects when used as prescribed. Any side effects or withdrawal symptoms usually resolve over time. Long-term safety studies have shown that it’s generally well-tolerated.

What happens if you stop taking bupropion suddenly?

Stopping buspirone abruptly can provoke withdrawal symptoms like irritability, mood swings, or flu-like symptoms. Gradually tapering off under a doctor’s guidance can prevent these effects and ensure a smoother transition.

How to Taper off Buspar and Get Effective Treatment for Anxiety Disorders at a Premier Rehab

If you need help weaning off buspirone, reach out to Renaissance Recovery. We can connect you with licensed medical detox centers near you where you can get help with a buspirone taper. After detoxing, you can move into ongoing outpatient treatment at one of our rehabs in California or Florida.

When you choose an outpatient program at Renaissance, you can continue living at home and meeting your daily commitments while addressing mental health issues like anxiety during therapy sessions at one of our beachside facilities.

The unique nature of all anxiety disorders means all our treatment plans are personalized. Therapies might include:

• Medication management
• Counseling
• Motivational therapies
• Talk therapies
• Group therapy
• Holistic treatments
• Family therapy
• Aftercare

Begin your long-term recovery from anxiety by calling 866-330-9449. 

Sources

[1] https://www.federalregister.gov/documents/2010/10/19/2010-26214/determination-that-buspar-buspirone-hydrochloride-tablets-10-milligrams-15-milligrams-and-30

[2] https://www.ncbi.nlm.nih.gov/sites/books/NBK531477/

[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC7770052/

[4] https://www.sciencedirect.com/science/article/abs/pii/0278584687900595